MDH2 Antibody

Datasheet

Code	CSB-PA013623ESR1HU
Size	US$166
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Image	Western blot All lanes: MDH2 antibody at 3µg/ml Lane 1: 293T whole cell lysate Lane 2: K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 36, 31 kDa Observed band size: 36 kDa Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA013623ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MDH2 Polyclonal antibody

Uniprot No.

P40926

Target Names

MDH2

Alternative Names

M MDH antibody; Malate dehydrogenase 2; NAD (mitochondrial) antibody; Malate dehydrogenase antibody; Malate dehydrogenase; mitochondrial antibody; MDH antibody; mdh2 antibody; MDHM_HUMAN antibody; MGC:3559 antibody; mitochondrial antibody; Mitochondrial malate dehydrogenase 2; NAD antibody; Mor 1 antibody; MOR1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Malate dehydrogenase, mitochondrial protein (59-338AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Gene References into Functions

these data suggest that MDH2, functioning as an RNA-binding protein, is involved in the posttranscriptional downregulation of SCN1A expression under seizure condition. PMID: 28433711
loss-of-function mutations in MDH2 are also associated with severe neurological clinical presentations in children PMID: 27989324
Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms. PMID: 25639359
Segregation of the mutation with disease and absence of MDH2 in mutated tumors revealed MDH2 as a novel pheochromocytoma/paraganglioma susceptibility gene. PMID: 25766404
L-2-hydroxyglutarate accumulates as a result of a deficiency in FAD-linked L-2-hydroxyglutarate dehydrogenase. mitochondrial L-malate dehydrogenase is responsible for the excretion of L-2-hydroxyglutarate in this condition. PMID: 17603759

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Involvement in disease

Epileptic encephalopathy, early infantile, 51 (EIEE51)

Subcellular Location

Mitochondrion matrix.

Protein Families

LDH/MDH superfamily, MDH type 1 family

Database Links

HGNC: 6971

OMIM: 154100

KEGG: hsa:4191

STRING: 9606.ENSP00000327070

UniGene: Hs.520967

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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