MYOG Antibody

Code CSB-PA015360LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MYOG Polyclonal antibody
Uniprot No.
Target Names
MYOG
Alternative Names
bHLHc3 antibody; cb553 antibody; Class C basic helix-loop-helix protein 3 antibody; MYF 4 antibody; Myf-4 antibody; MYF4 antibody; MYOG antibody; MYOG_HUMAN antibody; Myogenic factor 4 antibody; Myogenic factor 4 myogenin antibody; Myogenin antibody; Myogenin myogenin factor 4 antibody; OTTHUMP00000039094 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Myogenin protein (1-224AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The MYOG Antibody (Product code: CSB-PA015360LA01HU) is Non-conjugated. For MYOG Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA015360LB01HU MYOG Antibody, HRP conjugated ELISA
FITC CSB-PA015360LC01HU MYOG Antibody, FITC conjugated
Biotin CSB-PA015360LD01HU MYOG Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.
Gene References into Functions
  1. Findings indicate a interplay between A-kinase anchoring protein 6 (AKAP6) and myogenin. PMID: 26563778
  2. results indicate that myogenin is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle PMID: 25044114
  3. Sustained GSK3beta activity represses a critical regulatory step in the myogenic cascade, contributing to the undifferentiated, proliferative phenotype in alveolar rhabdomyosarcoma. PMID: 24577092
  4. Our study illustrates that focal myogenin immunoreactivity occurs uncommonly in fibroepithelial polyps of the lower female genital tract. PMID: 23944986
  5. Data indicate that muscle MYOG mRNA expression doubled, whereas MSTN protein expression decreased following immobilization. PMID: 24215591
  6. the FACT complex promotes myogenin-dependent transcription PMID: 23364797
  7. Human muscle samples were analysed at different time-points post-denervation to evaluate changes in myogenin expression and their relationship with skeletal muscle atrophy. PMID: 21672341
  8. After 2 years of denervation, expression of myogenin protein in myonuclei was decreased, but after 3 years of denervation, no expression of myogenin protein in myonuclei was found in denervated posterior cricoarytenoid muscles. PMID: 19961777
  9. The physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under Tetradecanoylphorbol Acetate -induced differentiation. PMID: 20213728
  10. study showed that a rapid rearrangement of myogenin expression occurs in exercised human skeletal muscles in response to a single bout of exercise PMID: 14997318
  11. myogenin and myocyte enhancer factor-2 expression are triggered by membrane hyperpolarization during human myoblast differentiation PMID: 15084602
  12. induction of Id1 not only blocks transcriptional activity but also induces myogenin degradation by blocking formation of myogenin-E47 protein complexes. PMID: 15322112
  13. there is a functional link between dysferlin and myogenin in the differentiation of skeletal muscle PMID: 16608842
  14. MYOG is a positive diagnostic for biliary tract rhabdomyosarcoma. PMID: 17378682
  15. MYOG had positive staining in this melanotic neuroectodermal tumor. PMID: 17378694
  16. Both PCAF and BRG1 are also involved in the activation of the myogenin gene in rhabdomyosarcoma PMID: 17468105
  17. transcription of Cugbp1 gene in muscle is regulated by myogenin and E proteins PMID: 17531403
  18. Diffuse myogenin expression by immunohistochemistry is an independent marker of poor survival in pediatric rhabdomyosarcoma. PMID: 18708938
  19. PAX3 mRNA is an Staufen 1-mediated mRNA decay target whose decay promotes myogenesis whereas myogenin mRNA is a classical nonsense-mediated mRNA decay target encoding a protein required for myogenesis PMID: 19095803
  20. Underexpression of myogenin is associated with liver metastases in rhabdomyosarcoma. PMID: 19372547
  21. Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. PMID: 19470832

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Subcellular Location
Nucleus.
Database Links

HGNC: 7612

OMIM: 159980

KEGG: hsa:4656

STRING: 9606.ENSP00000241651

UniGene: Hs.2830

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