MYOM1 Antibody

Datasheet

Code	CSB-PA015361GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P52179

Target Names

MYOM1

Alternative Names

190 kDa connectin-associated protein antibody; 190 kDa titin-associated protein antibody; EH myomesin antibody; MGC134946 antibody; MGC134947 antibody; MYOM1 antibody; MYOM1_HUMAN antibody; Myomesin (M protein) 1 (190kD) antibody; Myomesin 1 (skelemin) 185kDa antibody; Myomesin 1 185kDa antibody; Myomesin 1, 185kDa antibody; Myomesin family member 1 antibody; Myomesin-1 antibody; Skelemin antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human MYOM1-Specific

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

Gene References into Functions

Crystal structure of the obscurin(-like-1):myomesin complex reveals a trans-complementation mechanism whereby an incomplete immunoglobulin-like domain assimilates an isoform-specific myomesin interdomain sequence. PMID: 27989621
individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF-1 splice forms in cultured myoblasts PMID: 25152160
myomesin could act as a highly elastic ribbon to maintain the overall structural organization of the sarcomeric M-band. PMID: 22347812
Our results suggest that the downregulation of MBNL proteins should lead to the abnormal splicing of MYOM1 exon 17a in DM1 muscle. PMID: 21794030
EH-myomesin levels were up-regulated at least 10 times in dilated cardiomyopathy patients compared to controls. PMID: 21069531
This missense mutation caused significant changes of biochemical and biophysical properties of myomesin fragments indicating a role in the pathogenesis of hypertrophic cardiomyopathy . PMID: 21256114
Results identify muscle-type creatine kinase as a binding partner of a central portion of myomesin and the closely related M-protein. PMID: 12972258
visco-elastic properties of myomesin might be crucial for the stability of the sarcomere PMID: 15890201

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Subcellular Location

Cytoplasm, myofibril, sarcomere, M line.

Database Links

HGNC: 7613

OMIM: 603508

KEGG: hsa:8736

STRING: 9606.ENSP00000348821

UniGene: Hs.464469

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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