OAS3 Antibody

Datasheet

Code	CSB-PA897591LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA897591LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA897591LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA897591LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) OAS3 Polyclonal antibody

Uniprot No.

Q9Y6K5

Target Names

OAS3

Alternative Names

(2-5'')oligo(A) synthase 3 antibody; 2 5' oligo(A) synthetase 3 antibody; 2 5'LIGO antibody; 2 5A synthetase 3 antibody; 2''-5''-oligoadenylate synthase 3 antibody; 2-5A synthase 3 antibody; MGC133260 antibody; OAS3 2' 5' oligoadenylate synthetase 3, 100kDa antibody; OAS3 antibody; OAS3_HUMAN antibody; p100 antibody; p100 OAS antibody; p100OAS antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human 2\'-5\'-oligoadenylate synthase 3 protein (424-565AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The OAS3 Antibody (Product code: CSB-PA897591LA01HU) is Non-conjugated. For OAS3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA897591LB01HU	OAS3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA897591LC01HU	OAS3 Antibody, FITC conjugated
Biotin	CSB-PA897591LD01HU	OAS3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

Gene References into Functions

Mitochondrial C11orf83 is a potent antiviral protein independent of interferon production; and knockdown of either OAS3 or RNase L impaired the antiviral capability of C11orf83. PMID: 28418037
Protein-coding rare variations on the OAS3 gene are associated with the coexistence of HBsAg and anti-HBs in patients with chronic hepatitis B infection in Chinese Han population. PMID: 29582521
The study findings suggest that the OAS3 rs1859330 G/A genetic polymorphism is associated with the severity of enterovirus 71 (EV71) infection, and that the A allele is a risk factor for the development of severe EV71 infection. PMID: 28444539
Here we report, to our knowledge, the first analysis of nuclear signal import in the pseudo enzymatic domain DI of human OAS3 PMID: 27379722
OAS3 displayed a higher affinity for dsRNA in intact cells than either OAS1 or OAS2, consistent with its dominant role in RNase L activation. PMID: 26858407
By means of an allelic association study of a cohort of 740 patients with dengue, the authors found a protective effect of OAS3_R381 against shock. PMID: 26063222
Common variation at 12q24.13 (OAS3 intron) influences chronic lymphocytic leukemia risk. PMID: 25363670
The combined high affinity for double-stranded RNA and the capability to produce 2'-5'-linked oligoadenylates of sufficient length to activate RNase L suggests that OAS3 is a potent activator of RNase L. PMID: 25275129
OAS are interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation [review] PMID: 17408844

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

2-5A synthase family

Tissue Specificity

Present at high level in placenta trophoblast.

Database Links

HGNC: 8088

OMIM: 603351

KEGG: hsa:4940

STRING: 9606.ENSP00000228928

UniGene: Hs.528634

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

NOD-like receptor signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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