PADI3 Antibody

Code CSB-PA891552LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA891552LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA891552LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PADI3 Polyclonal antibody
Uniprot No.
Target Names
PADI3
Alternative Names
PADI3 antibody; PADI3_HUMAN antibody; PDI3 antibody; Peptidyl arginine deiminase; type III antibody; Peptidylarginine deiminase III antibody; Protein arginine deiminase type 3 antibody; Protein arginine deiminase type III antibody; Protein-arginine deiminase type III antibody; Protein-arginine deiminase type-3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein-arginine deiminase type-3 protein (1-664AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PADI3 Antibody (Product code: CSB-PA891552LA01HU) is Non-conjugated. For PADI3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA891552LB01HU PADI3 Antibody, HRP conjugated ELISA
FITC CSB-PA891552LC01HU PADI3 Antibody, FITC conjugated
Biotin CSB-PA891552LD01HU PADI3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the deimination of arginine residues of proteins.
Gene References into Functions
  1. The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation. PMID: 27866708
  2. Crystals of PAD3 obtained using polyethylene glycol 400 as a precipitant diffracted to 2.95 A resolution using synchrotron radiation PMID: 22684066
  3. PAD3 is co-located with filaggrin within the filamentous matrix of the deeper corneocytes where the protein is deiminated. PMID: 16091842
  4. PADI3 expression is driven by Sp1/Sp3 and NF-Y binding to the promoter region PMID: 16671893
  5. cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3) PMID: 18083705
  6. Peptidylarginine deiminase Intergenic Enhancer is a strong enhancer of the PADI3 promoter in Ca2+-differentiated epidermal keratinocytes, and requires bound PMID: 18923650
  7. These results reveal the molecular bases of the expression specificity of PADI1 and PADI3 during keratinocyte differentiation through a long-range enhancer and support a model of PADI gene regulation depending on c-Jun-JunD competition. PMID: 18952102

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Involvement in disease
Uncombable hair syndrome 1 (UHS1)
Subcellular Location
Cytoplasm.
Protein Families
Protein arginine deiminase family
Tissue Specificity
Hair follicles, and epidermis at very low levels.
Database Links

HGNC: 18337

OMIM: 191480

KEGG: hsa:51702

STRING: 9606.ENSP00000364609

UniGene: Hs.149195

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