PEG3 Antibody

1. Data suggest that PEG3 is required for TFEB induction and nuclear translocation in a VEGFR2- and AMPK-dependent manner for decorin/decorin receptor-evoked autophagy. (PEG3 = paternally expressed 3 protein; TFEB = transcription factor EB; VEGFR2 = vascular endothelial growth factor receptor-2; AMPK = AMP-activated protein kinase) PMID: 28798237
2. Peg3 transcriptionally modulates BECN1 activity. PMID: 28174297
3. Data indicate that a set of cis-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain. PMID: 27104590
4. In the current study, the authors have identified three alternative promoters for mouse Peg3 and one alternative promoter for human PEG3. PMID: 27075691
5. A resident population of resident smooth muscle progenitor cells expressing PW1 was identified in pulmonary hypertension-associated vascular remodeling. PMID: 26838788
6. PW1/Peg3 function is essential for conferring proper mesoangioblast competence and it's level in human mesoangioblasts may serve as a biomarker to identify donor populations for therapeutic application in muscular dystrophies. PMID: 25751651
7. The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion. PMID: 23936039
8. Genetic translocations involving PEG3 gene is associated with mesenchymal hamartoma of the liver. PMID: 24120702
9. we have unveiled a mechanism for a secreted proteoglycan in inducing Peg3, a master regulator of macroautophagy in endothelial cells PMID: 23798385
10. Results show that a five percent increase in DNA methylation of PEG3 is associated with a 1.6-fold increase invasive cervical cancer (ICC) risk. PMID: 23418553
11. None of the folate cycle genotypes in the mother or infant were related to the methylation of IGF2, PEG3, or LINE-1. PMID: 23151531
12. PEG3 gene is imprinted, with preferential expression from the paternal allele in human placenta. PMID: 11331620
13. mammalian imprinting utilizes Peg3/Pw1 to co-opt the Wnt pathway, thereby regulating development and glioma growth PMID: 20064927
14. Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death PMID: 11943780
15. These results support a model in which pEg3 contributes to the control of progression through mitosis by phosphorylation of the CDC25 phosphatases. PMID: 15908796
16. Loss of PEG3 expression may be a frequent event in gynecologic cancers. Given the known role of PEG3 in p53-mediated apoptosis, it is possible that PEG3 functions as a tumor suppressor. PMID: 16023706
17. These results suggest that pEg3 might play a role at the cell cortex during mitosis. PMID: 16159311
18. Down-regulation of PEG3 due to loss of heterozygosity and promoter methylation is associated with ovarian cancers PMID: 18286529
19. abnormal regulation of PEG3 is associated with several glioma subtypes and that it plays an important role in tumorigenesis. PMID: 19367087
20. PEG3 imprinted domain of humans, cows, and mice contains differing numbers of differentially methylated regions (DMR), but the PEG3-CpG island is the only DMR that is conserved among these three species. PMID: 19397955

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HGNC: 8826

OMIM: 601483

KEGG: hsa:5178

STRING: 9606.ENSP00000326581

UniGene: Hs.731875