PITRM1 Antibody

Datasheet

Code	CSB-PA692283ESR2HU
Size	US$166
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Image	Western blot All lanes: PITRM1 antibody at 2.42μg/ml Lane 1: Mouse placenta tissue Lane 2: A549 whole cell lysate Lane 3: Rat gonad tissue Lane 4: Mouse kidney tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 118, 107 kDa Observed band size: 118, 50 kDa Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA692283ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA692283ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PITRM1 Polyclonal antibody

Uniprot No.

Q5JRX3

Target Names

PITRM1

Alternative Names

hMP1 antibody; hPreP antibody; KIAA1104 antibody; Metalloprotease 1 antibody; MGC138192 antibody; MGC141929 antibody; mitochondrial antibody; MP1 antibody; Pitrilysin metallopeptidase 1 antibody; Pitrilysin metalloproteinase 1 antibody; PITRM 1 antibody; PITRM1 antibody; PreP antibody; PreP peptidasome antibody; PREP_HUMAN antibody; Presequence protease antibody; Presequence protease mitochondrial antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human Presequence protease, mitochondrial protein (758-1037AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently.

Gene References into Functions

Redox control of hPreP in the mitochondrial matrix and the protective role of the conserved methionine 206 residue as an internal antioxidant. PMID: 23041349
The authors identified two siblings carrying a homozygous PITRM1 missense mutation (c.548G>A, p.Arg183Gln) associated with an autosomal recessive, slowly progressive syndrome characterised by mental retardation, spinocerebellar ataxia, cognitive decline and psychosis. PMID: 26697887
Data show that the hPreP presequence only targets GFP to the matrix of mammalian and yeast mitochondria. PMID: 21621546
This study demonstrated decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria. PMID: 21750375
our data suggest that genetic variation in the hPreP gene PITRM1 may potentially contribute to mitochondrial dysfunctions PMID: 19962426
The substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and its mitochondrial targeting signal identified. PMID: 19196155
Data revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of chronic kidney disease. PMID: 19724895

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Subcellular Location

Mitochondrion matrix.

Protein Families

Peptidase M16 family, PreP subfamily

Tissue Specificity

Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.

Database Links

HGNC: 17663

KEGG: hsa:10531

STRING: 9606.ENSP00000370377

UniGene: Hs.528300

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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