PITRM1 is a protein in humans that is encoded by PITRM1 gene. Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently.
The following PITRM1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PITRM1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA018041GA01HU | PITRM1 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA692283ESR1HU | PITRM1 Antibody |
Human, Mouse | ELISA, WB, IHC |
CSB-PA692283ESR2HU | PITRM1 Antibody |
Human, Mouse, Rat | ELISA, WB, IHC |
PITRM1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA770391XA01DIL | pitrm1 Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
PITRM1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Code | Product Name | Source |
---|---|---|
CSB-YP634696XBF CSB-EP634696XBF CSB-BP634696XBF CSB-MP634696XBF CSB-EP634696XBF-B |
Recombinant Xenopus tropicalis Presequence protease, mitochondrial (pitrm1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PITRM1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP692283HU CSB-EP692283HU CSB-BP692283HU CSB-MP692283HU CSB-EP692283HU-B |
Recombinant Human Presequence protease, mitochondrial (PITRM1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PITRM1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP716198PYX CSB-EP716198PYX CSB-BP716198PYX CSB-MP716198PYX CSB-EP716198PYX-B |
Recombinant Pongo abelii Presequence protease, mitochondrial (PITRM1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PITRM1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP764793XBE CSB-EP764793XBE CSB-BP764793XBE CSB-MP764793XBE CSB-EP764793XBE-B |
Recombinant Xenopus laevis Presequence protease, mitochondrial (pitrm1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PITRM1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP770391DIL CSB-EP770391DIL CSB-BP770391DIL CSB-MP770391DIL CSB-EP770391DIL-B |
Recombinant Danio rerio Presequence protease, mitochondrial (pitrm1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PITRM1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP811711MO CSB-EP811711MO CSB-BP811711MO CSB-MP811711MO CSB-EP811711MO-B |
Recombinant Mouse Presequence protease, mitochondrial (Pitrm1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |