PLIN5 Antibody

Code CSB-PA804867LA01HU
Size US$166
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Image
  • Western blot
    All lanes: PLIN5 antibody at 2 μg/ml
    Lane 1: Mouse kidney tissue
    Lane 2: Mouse brain tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 51 kDa
    Observed band size: 51, 36 kDa

  • Immunofluorescent analysis of HepG2 cells using CSB-PA804867LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PLIN5 Polyclonal antibody
Uniprot No.
Target Names
PLIN5
Alternative Names
Lipid storage droplet protein 5 antibody; LSDA5 antibody; MLDP antibody; OXPAT antibody; Perilipin 5 antibody; Perilipin-5 antibody; PLIN5 antibody; PLIN5_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Perilipin-5 protein (305-453AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PLIN5 Antibody (Product code: CSB-PA804867LA01HU) is Non-conjugated. For PLIN5 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA804867LB01HU PLIN5 Antibody, HRP conjugated ELISA
FITC CSB-PA804867LC01HU PLIN5 Antibody, FITC conjugated
Biotin CSB-PA804867LD01HU PLIN5 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The PLIN5 polyclonal antibody is inducibly produced in the rabbit immunized with the recombinant human PLIN5 (305-453aa). It exists as the IgG isotype and liquid form. And it is purified by protein G affinity chromatography and reaches up to 95% in purity. This PLIN5 antibody can react with human- and mouse-origin PLIN5 proteins. It can recognize and detect the PLIN5 protein in three applications, including ELISA, WB, and IF.

Its target protein PLIN5, also known as OXPAT, mainly regulates lipid metabolism, particularly fatty acid oxidation, in different tissues. Its role in energy metabolism and glucose homeostasis suggests that PLIN5 may have important implications for metabolic diseases, such as obesity, diabetes, and cardiovascular disease.

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Target Background

Function
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
Gene References into Functions
  1. The data highlight a key role of PLIN5 in lipid droplets function, first by finely adjusting lipid droplets fatty acids supply to mitochondrial oxidation, and second acting as a protective factor against lipotoxicity in skeletal muscle. PMID: 27922115
  2. Notch1 expression is reduced and glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in liver biopsies from nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) patients. PMID: 27428080
  3. High oxygen consumption in middle-aged men was reflected in higher perilipin 5 expression in skeletal muscle. PMID: 26447519
  4. PLIN5 was significantly colocated with ATGL, mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle. PMID: 25054327
  5. Perilipin 5 as a lipid droplet protein adapted to mitochondrial energy utilization PMID: 24535284
  6. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5 PMID: 23129790
  7. PLIN5 likely plays an important role in intramyocellular lipid accumulation and oxidation, both of which increase with endurance training in human skeletal muscle. PMID: 22667335
  8. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. PMID: 22127648
  9. Perilipin 5 is the most recently established family member, highly expressed in oxidative tissues and could play an important role in regulating LD TAG hydrolysis in oxidative mammalian tissues. [Review] PMID: 21632259
  10. interaction of ATGL with CGI-58 increased lipolysis, whereas interaction of ATGL with perilipin 5 decreased lipolysis. PMID: 21393244
  11. Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes. PMID: 19602560

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Subcellular Location
Lipid droplet. Cytoplasm. Mitochondrion.
Protein Families
Perilipin family
Tissue Specificity
Expressed in skeletal muscle, liver, heart and kidney.
Database Links

HGNC: 33196

OMIM: 613248

KEGG: hsa:440503

STRING: 9606.ENSP00000371272

UniGene: Hs.131034

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