PMPCB Antibody

Code CSB-PA018243ESR2HU
Size US$166
Order now
Image
  • Western blot
    All lanes: PMPCB antibody at 0.69 μg/ml
    Lane 1: Mouse heart tissue
    Lane 2: Mouse kidney tissue
    Lane 3: Mouse liver tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 54 kDa
    Observed band size: 54 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA018243ESR2HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PMPCB Polyclonal antibody
Uniprot No.
Target Names
PMPCB
Alternative Names
Beta MPP antibody; Beta-MPP antibody; BetaMPP antibody; Mitochondrial processing peptidase subunit beta antibody; Mitochondrial-processing peptidase subunit beta antibody; MPP11 antibody; MPPB antibody; MPPB_HUMAN antibody; MPPP52 antibody; P 52 antibody; P-52 antibody; P52 antibody; Peptidase mitichondrial processing beta antibody; PMPCB antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Mitochondrial-processing peptidase subunit beta protein (110-380AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis.
Gene References into Functions
  1. biallelic mutations in PMPCB cause defects in MPP proteolytic activity leading to dysregulation of iron-sulfur cluster biogenesis and triggering a complex neurological phenotype of neurodegeneration in early childhood. PMID: 29576218
  2. OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase. PMID: 24903103
  3. These results highlight a new role for MPP in PINK1 import and mitochondrial quality control via the PINK1-Parkin pathway. PMID: 22354088
  4. maintained expression and even up-regulation of some (PNPT1, PMPCB, HMMR/RHAMM, BSG and ERCC1) tumor associated antigens in CD40-activated leukemic cells. PMID: 19580345
Subcellular Location
Mitochondrion matrix.
Protein Families
Peptidase M16 family
Database Links

HGNC: 9119

OMIM: 603131

KEGG: hsa:9512

STRING: 9606.ENSP00000249269

UniGene: Hs.184211

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*