PPP1R3C Antibody

Code CSB-PA030174
Size US$100
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Product Details

Uniprot No.
Target Names
PPP1R3C
Alternative Names
OTTHUMP00000020089 antibody; Phosphatase 1, regulatory inhibitor subunit 5 antibody; PP1 subunit R5 antibody; ppp1r3c antibody; PPP1R5 antibody; PPR3C_HUMAN antibody; Protein phosphatase 1 inhibitor 3C antibody; Protein phosphatase 1 regulatory subunit 3C antibody; Protein phosphatase 1 regulatory subunit 5 antibody; protein phosphatase 1, regulatory (inhibitor) subunit 3C antibody; Protein targeting to glycogen antibody; PTG antibody; R5 antibody
Raised in
Rabbit
Species Reactivity
Human,Monkey
Immunogen
Synthesized peptide derived from the Internal region of Human PTG.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
Gene References into Functions
  1. PPP1R3C, a novel hypermethylated gene in colorectal cancer, may play a critical role in cancer cell growth in association with glucose levels. PMID: 25846879
  2. detection of methylation of PPP1R3C alone or in combination with EFHD1 in plasma DNA showed high sensitivity and specificity in CRC detection, and may be useful detection method for CRC, especially for early-stage CRCs. PMID: 24861485
  3. Findings suggest that variations in PTG may condition the course of Lafora disease and establish PTG as a potential target for pharmacogenetic and therapeutic approaches. PMID: 21738631
  4. Results demonstrated that HIF1 promotes glycogen accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia. PMID: 20888814
  5. phosphorylation of R5/PTG at Ser-8 by AMPK accelerates its laforin/malin-dependent ubiquitination and subsequent proteasomal degradation, which results in a decrease of its glycogenic activity. PMID: 19171932

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Database Links

HGNC: 9293

OMIM: 602999

KEGG: hsa:5507

STRING: 9606.ENSP00000238994

UniGene: Hs.303090

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