PRMT2 Antibody

Code CSB-PA018732ESR1HU
Size US$166
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  • Western blot
    All lanes: PRMT2 antibody at 4µg/ml + HL60 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 50, 32, 38, 33, 34, 26, 32 kDa
    Observed band size: 50 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA018732ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018732ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PRMT2 Polyclonal antibody
Uniprot No.
Target Names
PRMT2
Alternative Names
ANM2_HUMAN antibody; EC 2.1.1. antibody; histone arginine N methyltransferase PRMT2 antibody; Histone-arginine N-methyltransferase PRMT2 antibody; HMT 1 antibody; HMT1 (hnRNP methyltransferase S. cerevisiae) like 1 antibody; HMT1 antibody; HMT1 hnRNP methyltransferase like 1 antibody; hnRNP methyltransferase (S. cerevisiae) like 1 antibody; hnRNP methyltransferase like 1 antibody; Hrmt1l1 antibody; MGC111373 antibody; PRMT 2 antibody; PRMT2 alpha antibody; prmt2 antibody; PRMT2 beta antibody; PRMT2 gamma antibody; PRMT2 protein antibody; PRMT2L2 antibody; Protein arginine methyltransferase 2 antibody; Protein arginine N methyltransferase 2 antibody; Protein arginine N-methyltransferase 2 antibody; Zf2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein arginine N-methyltransferase 2 protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Gene References into Functions
  1. Results show that tamoxifen resistance in breast cancer cells is connected with the downregulation of PRMT2 and the upregulation of ER-alpha36. Moreover, PRMT2 was able to interact with ER-alpha36 directly, suppress ER-alpha36 and downstream PI3K/Akt and MAPK/ERK signaling, reversing the tamoxifen resistance of breast cancer cells. PMID: 29620287
  2. Low splice variant of PRMT2 expression is associated with breast cancer. PMID: 28677794
  3. Cobl-mediated dendritic arborization required PRMT2, complex formation with PRMT2, and PRMT2's catalytic activity PMID: 29689199
  4. The PRMT2 interacts with SAM68 in cells and regulates its subcellular localization via the SH3 domain of PRMT2, prompting us to investigate the potential role of PRMT2 in BCL-X alternative splicing. PMID: 28057797
  5. This study demonstrates the role and significant correlation between a histone methyltransferase (PRMT2)-dependent signature, RORgamma, the cell-cycle regulation, DNA repair circuits, and breast cancer survival outcomes. PMID: 24911119
  6. This study uncovers the molecular mechanism of PRMT2 regulating the expression of CCND1 in invasive ductal breast carcinoma. PMID: 24292672
  7. characterization of 3 PRMT2 splice variants (PRMT2alpha, PRMT2beta, and PRMT2gamma) from breast cancer; these variants bind to ERalpha in vitro/in vivo; overall PRMT2 expression is upregulated in breast cancer and associated w/ ERalpha positivity PMID: 22093364
  8. Data suggest that post-transcriptional processing mechanism as alternative polyadenylation and splicing may play a crucial role in regulating human PRMT2 gene expression. PMID: 21820040
  9. the SH3 domain may mediate an interaction between PRMT1 and -2 in a methylation-dependent fashion PMID: 21851090
  10. PRMT2 is a novel ERalpha coactivator. PMID: 12039952
  11. PRMT2 inhibits NF-kappa B function and promotes apoptosis. PMID: 16648481
  12. ligand-dependent AR conformation is essential for the recruitment and nuclear translocation of PMRT2 which acts as AR-coactivator, presumably by arginine methylation. PMID: 17587566
  13. Here we report methylation activity from PRMT2 and compare it with PRMT1 activity using UPLC-MS/MS (ultra-performance liquid chromatography-tandem MS), gel electrophoresis, and thin-layer chromatography PMID: 19405910

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Subcellular Location
[Isoform 1]: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.; [Isoform PRMT2Alpha]: Nucleus. Note=Excluded from nucleolus.; [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus.; [Isoform PRMT2Gamma]: Nucleus. Note=Excluded from nucleolus.; [Isoform PRMT2L2]: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Protein Families
Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family
Tissue Specificity
Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
Database Links

HGNC: 5186

OMIM: 601961

KEGG: hsa:3275

STRING: 9606.ENSP00000347906

UniGene: Hs.154163

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