PRND Antibody

Datasheet

Code	CSB-PA890741ESR1HU
Size	US$166
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Image	Western blot All lanes: Prion-like protein doppel antibody at 2μg/ml + Mouse spleen tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 20 kDa Observed band size: 20 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA890741ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PRND Polyclonal antibody

Uniprot No.

Q9UKY0

Target Names

PRND

Alternative Names

dJ1068H6.4 antibody; DPL antibody; Dublet antibody; MGC41841 antibody; Prion gene complex downstream antibody; Prion like protein doppel antibody; Prion protein 2 (dublet) antibody; Prion protein 2 antibody; Prion-like protein doppel antibody; PRND antibody; PRND_HUMAN antibody; PrPLP antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Prion-like protein doppel protein (20-160AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Required for normal acrosome reaction and for normal male fertility. Can bind Cu(2+).

Gene References into Functions

results demonstrate that blocking doppel can control VEGF signaling in TECs and selectively inhibit tumor angiogenesis. PMID: 26950422
The association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with Alzheimer's disease and mild cognitive impairment, was evaluated. PMID: 22453181
in astrocytomas, Dpl undergoes different molecular processes that might constitute additional helpful tools to characterize the glial tumor progression PMID: 20981146
Cytotoxicity induced by the expression of Dpl and truncated PrP in neural derived cells are closely related with the apoptosis process. PMID: 19728151
expression pattern and biochemical characteristics in human tissues and in Chinese hamster ovary cells transfected with wild-type or variant human Dpl gene constructs PMID: 12200435
Doppel expression is not modified in the brains of patients with Creutzfeldt-Jakob disease. PMID: 12586339
human Doppel fails to interact with itself; Dpl and PrP are not related or are only marginally related with respect to their ligand binding behaviour PMID: 15158907
results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane PMID: 15203115
Doppel interacts with the full-length laminin receptor precursor protein PMID: 15246873
Doppel is expressed early during ontogenesis, and is found in both germ cells and Sertoli cells. Doppel may play a physiological role in acrosome biogenesis. PMID: 16421231
Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes. PMID: 17390034
Study provides the foundation for further study of Dpl biological functions in vitro and in vivo. PMID: 17894227
Results might suggest a potential and functional role for Dpl in tumor cells migratory and morphological behaviours and address to future gene-targeted therapeutic interventions. PMID: 18936526
results suggested that the function of Dpl is antagonistic to PrP rather than synergistic PMID: 19129949

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Families

Prion family

Tissue Specificity

Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).

Database Links

HGNC: 15748

OMIM: 604263

KEGG: hsa:23627

STRING: 9606.ENSP00000306900

UniGene: Hs.406696

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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