PRRX1 Antibody

1. Low PRRX1 expression is associated with hepatocellular carcinoma. PMID: 28677793
2. identified a functional genetic variant that alters PRRX1 expression, ultimately resulting in electrophysiological alterations in atrial myocytes that may promote Atrial fibrillation. PMID: 28974514
3. The glioma-initiating cells self-renewal function regulated by PRRX1 is mediated by dopamine D2 receptor (DRD2). PRRX1 directly binds to the DRD2 promoter and transactivates its expression in glioma-initiating cells. PMID: 28486630
4. LGR5-expressing fraction of CD54+ cells represents gastric cancer CSCs, in which LGR5 is closely associated with stemness and EMT core genes PMID: 28033430
5. Prrx1b may be an important regulator of epithelial-mesenchymal transition in Triple-negative breast cancer cells. PMID: 27027510
6. miR-655 inhibits the acquisition of the epithelial-mesenchymal transition phenotype in triple-negative breast cancer by down-regulating Prrx1, thereby inhibiting cell migration and invasion during cancer progression. PMID: 26820102
7. Decreased Expression of PRRX1 was Associated with Hepatocellular Carcinoma. PMID: 25404478
8. the switch from Prrx1b to Prrx1a governs EMT plasticity in both mouse models of PDAC and human PDAC PMID: 26773005
9. These findings demonstrate that PRRX1 promotes epithelial-mesenchymal transition in gastric cancer cells PMID: 25428393
10. Our results indicate that activation of Notch signaling by PRRX1 is associated with the promotion of glioblastoma cell invasion. PMID: 25522823
11. We conclude that miR-146b-5p has a role in cell proliferation and invasion, and that PRRX1 plays an important role in papillary thyroid carcinoma epithelial-mesenchymal transition and disease progression. PMID: 24946010
12. Overexpression of PRRX1 in stably overexpressed-miR-124 cell lines could rescue the effects of radiosensitivity enhancement brought by miR-124. PMID: 24705396
13. In the rare variant joint analysis, damaging variants within the PRRX1 region showed significant association with AF. PMID: 24239840
14. PRRX1 is an indicator of metastasis and poor prognosis in colorectal cancer cases. PMID: 23807160
15. The homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. PMID: 23201163
16. We show that the homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. The loss of Prrx1 is required for cancer cells to metastasize in vivo, which revert to the epithelial phenotype concomitant with the acquisition of stem cell properties. PMID: 23201163
17. Mutation analysis was performed after sequencing the entire coding regions of OTX2 and PRRX1 genes isolated from the proband and his parents. After thorough analysis, no DNA variations were detected. PMID: 22198066
18. identification of the two Prx1 target genes, which play a pivotal role in development of liver fibrosis, is a novel finding for liver pathophysiology PMID: 18296734

Show More

Hide All

HGNC: 9142

OMIM: 167420

KEGG: hsa:5396

STRING: 9606.ENSP00000239461

UniGene: Hs.283416