SLC27A5 Antibody

Code CSB-PA876368
Size US$297
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  • Western blot analysis of extracts from HepG2 cells, using SLC27A5 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using SLC27A5 antibody.
  • Immunofluorescence analysis of A549 cells, using SLC27A5 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC27A5 Polyclonal antibody
Uniprot No.
Target Names
SLC27A5
Alternative Names
ACSB antibody; ACSVL6 antibody; BA CoA ligase antibody; BA-CoA ligase antibody; BACS antibody; BAL antibody; Bile acid CoA ligase antibody; Bile acid-CoA ligase antibody; Bile acyl CoA synthetase antibody; Bile acyl-CoA synthetase antibody; Cholate CoA ligase antibody; Cholate--CoA ligase antibody; FACVL3 antibody; FATP 5 antibody; FATP-5 antibody; FATP5 antibody; Fatty acid Coenzyme A ligase very long chain 3 antibody; Fatty acid transport protein 5 antibody; Fatty-acid-coenzyme A ligase antibody; FLJ22987 antibody; S27A5_HUMAN antibody; Slc27a5 antibody; Solute carrier family 27 (fatty acid transporter) member 5 antibody; Solute carrier family 27 member 5 antibody; Very long chain acyl CoA synthetase homolog 2 antibody; Very long chain acyl CoA synthetase related protein antibody; very long-chain 3 antibody; Very long-chain acyl-CoA synthetase homolog 2 antibody; Very long-chain acyl-CoA synthetase-related protein antibody; VLACS related antibody; VLACS-related antibody; VLACSR antibody; VLCS H2 antibody; VLCS-H2 antibody; VLCSH2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human SLC27A5.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates. Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Exhibits long-chain fatty acids (LCFA) transport activity. Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids.
Gene References into Functions
  1. Based on a study of 10 pediatric patients, genetic defects that disrupt bile acid amidation cause fat-soluble vitamin deficiency and growth failure, indicating the importance of bile acid conjugation in lipid absorption. PMID: 23415802
  2. Bile acid-CoA ligase deficiency is a new inborn error of bile acid metabolism [case report] PMID: 22089923
  3. A promoter polymorphism in the FATP5 is associated with the metabolic syndrome and steatosis. PMID: 20945272
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome. Cell membrane; Multi-pass membrane protein.
Protein Families
ATP-dependent AMP-binding enzyme family
Tissue Specificity
Predominantly expressed in liver.
Database Links

HGNC: 10999

OMIM: 603314

KEGG: hsa:10998

STRING: 9606.ENSP00000263093

UniGene: Hs.292177

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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