SLC35A2 Antibody

Code CSB-PA021584LA01HU
Size US$166
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Image
  • IHC image of CSB-PA021584LA01HU diluted at 1:150 and staining in paraffin-embedded human prostate.cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • Western Blot
    Positive WB detected in: 293 whole cell lysate, PC-3 whole cell lysate, MCF7 whole cell lysate, Hela whole cell lysate, Jurkat whole cell lysate, HepG2 whole cell lysate, SH-SY5Y whole cell lysate All lanes:SLC35A2 Antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 41 kDa
    Observed band size: 41 kDa
  • Western Blot
    Positive WB detected in: Mouse Brain tissue lysate, Rat Brain tissue lysate
    All lanes:SLC35A2 Antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 41 kDa
    Observed band size: 41 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC35A2 Polyclonal antibody
Uniprot No.
Target Names
SLC35A2
Alternative Names
SLC35A2 antibody; UGALT antibody; UGT antibody; UGTL antibody; UDP-galactose translocator antibody; Solute carrier family 35 member A2 antibody; UDP-galactose transporter antibody; UDP-Gal-Tr antibody; UGT antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse,Rat
Immunogen
Synthesized peptide derived from human SLC35A2
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:3000
IHC 1:100-1:300
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function
Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.
Gene References into Functions
  1. The short N-terminal region composed of 35 N-terminal amino-acid residues of UGT was crucial for galactosylation of N-glycans. PMID: 25451267
  2. UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats). PMID: 25944901
  3. De novo mutations in SLC35A2 encoding a UDP-galactose transporter cause early-onset epileptic encephalopathy. PMID: 24115232
  4. The data further supports the hypothesis that UGT and NGT cooperate in the UDP-Gal delivery for glycosyltransferases located in the Golgi apparatus. PMID: 23583405
  5. Mosaicism of the UDP-galactose transporter SLC35A2 causes a congenital disorder of glycosylation. PMID: 23561849
  6. localization of the UDP-Gal transporter may depend on the presence of the partner splice variant PMID: 21918738

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Involvement in disease
Congenital disorder of glycosylation 2M (CDG2M)
Subcellular Location
Golgi apparatus membrane; Multi-pass membrane protein.
Protein Families
Nucleotide-sugar transporter family, SLC35A subfamily
Database Links

HGNC: 11022

OMIM: 300896

KEGG: hsa:7355

STRING: 9606.ENSP00000247138

UniGene: Hs.21899

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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