TMEM65 Antibody

Code CSB-PA023869LA01HU
Size US$600
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  • Western Blot
    Positive WB detected in: PC-3 whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate, 293 whole cell lysate, SH-SY5Y whole cell lysate, Mouse brain tissue
    All lanes: TMEM65 antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 26 KDa
    Observed band size: 20-25 KDa
    Exposure time:5min
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TMEM65 Polyclonal antibody
Uniprot No.
Target Names
TMEM65
Alternative Names
TMEM65; Transmembrane protein 65
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Transmembrane protein 65 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TMEM65 Antibody (Product code: CSB-PA023869LA01HU) is Non-conjugated. For TMEM65 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA023869LB01HU TMEM65 Antibody, HRP conjugated ELISA
FITC CSB-PA023869LC01HU TMEM65 Antibody, FITC conjugated
Biotin CSB-PA023869LD01HU TMEM65 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The use of recombinant human Transmembrane protein 65 protein to immunize the rabbit, subsequent collection of the rabbit serum, and the final isolation and purification of the antibody using antigen affinity method were used to produce the TMEM65 polyclonal antibody.

The TMEM65 polyclonal antibody shows reactivity with TMEM65 protein from human and mouse samples. It has been validated to recognize TMEM65 protein in the ELISA and WB applications, suggesting the usefulness of this TMEM65 polyclonal antibody in various experimental settings.

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Target Background

Function
May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication. May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance.
Gene References into Functions
  1. A novel homozygous splice variant (c.472+1G>A) in the TMEM65 gene identified in a patient with mitochondrial encephalomyopathy. TMEM65 mutation severely affected mitochondrial content and respiration rate in dermal fibroblasts. PMID: 28295037
Involvement in disease
Defects in TMEM65 may cause a mitochondrial disorder characterized by a complex encephalomyopathic phenotype. Clinical features includ microcephaly, dysmorphic features, psychomotor regression, hypotonia, growth retardation, lactic acidosis, intractable seizures, dyskenetics movements, without cardiomyopathy (PubMed:28295037).
Subcellular Location
Cell membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
Tissue Specificity
Predominantly expressed the ventricular tissue (at protein level).
Database Links

HGNC: 25203

OMIM: 616609

KEGG: hsa:157378

STRING: 9606.ENSP00000297632

UniGene: Hs.100691

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