TRIM31 Antibody

Code CSB-PA024468GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TRIM31
Alternative Names
TRIM31 antibody; C6orf13 antibody; RNF antibody; E3 ubiquitin-protein ligase TRIM31 antibody; EC 2.3.2.27 antibody; RING-type E3 ubiquitin transferase TRIM31 antibody; Tripartite motif-containing protein 31 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human TRIM31
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulator of Src-induced anchorage independent cell growth. May have E3 ubiquitin-protein ligase activity.
Gene References into Functions
  1. knockdown of TRIM31 reduced the expression of MMP2, MMP9 and phospho-Akt. PMID: 29864908
  2. TRIM31 could promote hepatocellular carcinoma progression by targeting TSC1-TSC2 complex for degradation and further overactivating mTORC1 pathway. PMID: 28967907
  3. feedback suppressor of NLRP3 inflammasome activity PMID: 27929086
  4. Study reports that TRIM31 plays a critical role in the formation of autolysosomes in Atg5-/-or Atg7-/- cells, thus promoting elimination of invading bacteria through an Atg5- or Atg7-independent alternative pathway in the intestinal cells. PMID: 27216961
  5. TRIM31 gene expression is regulated by miR-551b in ovarian cancer. PMID: 27743201
  6. TRIM31 directly binds to NSE4, suggesting the existence of a TRIM31-MAGEA1-NSE4 complex reminiscent of the NSE1-NSE3-NSE4 trimer. PMID: 25590999
  7. TRIM31 might serve as a tumor suppressor in non-small cell lung cancer. PMID: 24566900
  8. The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system. PMID: 21231912
  9. The TRIm31 gene is related to intelligence in an ADHD background. PMID: 21302343

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Subcellular Location
Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.
Protein Families
TRIM/RBCC family
Tissue Specificity
Up-regulated in gastric adenocarcinomas.
Database Links

HGNC: 16289

OMIM: 609316

KEGG: hsa:11074

STRING: 9606.ENSP00000365924

UniGene: Hs.493275

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