TRIM31 Antibody

Code CSB-PA290336
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA290336(TRIM31 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA290336(TRIM31 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human stomach cancer tissue, Primary antibody: CSB-PA290336(TRIM31 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
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Product Details

Uniprot No.
Target Names
TRIM31
Alternative Names
TRIM31 antibody; C6orf13 antibody; RNF antibody; E3 ubiquitin-protein ligase TRIM31 antibody; EC 2.3.2.27 antibody; RING-type E3 ubiquitin transferase TRIM31 antibody; Tripartite motif-containing protein 31 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Fusion protein of Human TRIM31
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:10-1:50
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulator of Src-induced anchorage independent cell growth. May have E3 ubiquitin-protein ligase activity.
Gene References into Functions
  1. knockdown of TRIM31 reduced the expression of MMP2, MMP9 and phospho-Akt. PMID: 29864908
  2. TRIM31 could promote hepatocellular carcinoma progression by targeting TSC1-TSC2 complex for degradation and further overactivating mTORC1 pathway. PMID: 28967907
  3. feedback suppressor of NLRP3 inflammasome activity PMID: 27929086
  4. Study reports that TRIM31 plays a critical role in the formation of autolysosomes in Atg5-/-or Atg7-/- cells, thus promoting elimination of invading bacteria through an Atg5- or Atg7-independent alternative pathway in the intestinal cells. PMID: 27216961
  5. TRIM31 gene expression is regulated by miR-551b in ovarian cancer. PMID: 27743201
  6. TRIM31 directly binds to NSE4, suggesting the existence of a TRIM31-MAGEA1-NSE4 complex reminiscent of the NSE1-NSE3-NSE4 trimer. PMID: 25590999
  7. TRIM31 might serve as a tumor suppressor in non-small cell lung cancer. PMID: 24566900
  8. The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system. PMID: 21231912
  9. The TRIm31 gene is related to intelligence in an ADHD background. PMID: 21302343

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Subcellular Location
Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.
Protein Families
TRIM/RBCC family
Tissue Specificity
Up-regulated in gastric adenocarcinomas.
Database Links

HGNC: 16289

OMIM: 609316

KEGG: hsa:11074

STRING: 9606.ENSP00000365924

UniGene: Hs.493275

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