Recombinant Human Eotaxin protein(CCL11) (Active)

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Code CSB-AP000901HU
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Product Details

Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration range of 0.1-10.0 ng/ml.
Target Names CCL11
Uniprot No. P51671
Research Area Immunology
Alternative Names C-C motif chemokine 11; CCL 11; CCL11; CCL11_HUMAN; chemokine (C-C motif) ligand 11; Chemokine C C motif ligand 11; Chemokine CC Motif Ligand 11; Chemokine ligand 11; Eosinophil chemotactic protein; Eotaxin; eotaxin-1; MGC22554; SCYA 11; SCYA11; Small inducible cytokine A11; Small inducible cytokine subfamily A (Cys Cys) member 11; small inducible cytokine subfamily A (Cys-Cys); member 11 (eotaxin); Small inducible cytokine subfamily A member 11; Small-inducible cytokine A11
Species Homo sapiens (Human)
Source E.coli
Expression Region 24-97aa
Mol. Weight 8.4 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, pH 7.4, 150 mM NaCl
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
Gene References into Functions
  1. These results suggest CCL11 as a candidate biomarker for the prediction of acute and long-term functional outcomes in ischemic stroke patients PMID: 28634890
  2. analyzed the genotypes of 6 tag SNPs in the CCL11 gene (rs1129844, rs17809012, rs1860183, rs1860184, rs4795898, and rs4795895) in a case control study. We found the GG genotype of rs4795895 was significantly associated with increased risk of lacunar stroke and the GA genotype of rs17809012 was associated with a significant increase in risk of LAA stroke PMID: 28873081
  3. CCL11 promotor polymorphism is associated with increased risk for the development of schizophrenia in a Korean population. PMID: 29477870
  4. Findings suggest that CCL11-CCR3 binding is involved in the progression of GBM. PMID: 27119233
  5. There were no significant differences in GE area of infertile and fertile women. C-C motif chemokine 11 (P=0.048), TGFalpha (P=0.049), IFNgamma (P=0.033) and interleukin-1 alpha (P=0.047) were significantly elevated in uterine lavage from infertile women <35years compared to fertile but not in women 35years PMID: 27525354
  6. eotaxin promotes proliferation in vascular smooth muscle cells and triggers oxidative stress in a NADPH oxidase dependent manner. PMID: 27681294
  7. a receiver operating characteristic (ROC) curve analysis demonstrated CSF CCL11 accurately distinguished CTE subjects from non-athlete controls and AD subjects PMID: 28950005
  8. These studies characterized serum and intestinal wall eotaxin-1 levels in various inflammatory bowel disease patients and to explore the effect of targeting eotaxin-1 by specific antibodies in dextran sodium sulfate-induced colitis model. PMID: 26874691
  9. this study shows that expression of CCL11 is increased in eosinophilic myocarditis patients compared to chronic lymphocytic myocarditis patients PMID: 27621211
  10. Review: eotaxins (CCL11, CCL24, and CCL26) play key role(s) during symptomatic inflammatory responses raised in response to allergic crisis of allergic asthma and atopic dermatitis PMID: 26861136
  11. increased amounts released by neutrophils from fibromyalgia patients PMID: 26341115
  12. Eotaxin measured on the day of birth is useful for identifying extremely low birth weight infants at risk of bronchopulmonary dysplasia/death. PMID: 26270578
  13. The results of this study suggested that eotaxin-1 as a novel modifier of Alzheimer's disease age at onset and open potential avenues for therapy. PMID: 26324103
  14. ANDV caused long-term elevated levels of eotaxin-1, IL-6, IL-8, IP-10, and VEGF-A that peaked 20-25 days after infection PMID: 26907493
  15. The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients. PMID: 26491210
  16. Findings demonstrate a link between CCL11 and primary Sjogren's syndrome disease activity and lymphoma. PMID: 26359802
  17. Serum and urinary CCL11 were decreased in patients with prostate cancer compared with controls. PMID: 26306920
  18. Results show the structure of CCL11 bound to the sulfated N-terminal region of its receptor CCR3 and show that intact CCR3 is sulfated and sulfation enhances receptor activity. PMID: 25450766
  19. SF of BC OA displayed significantly higher concentrations for a number of proinflammatory cytokines [CXCL1, eotaxin, interferon (IFN)-gamma, interleukin (IL)-7, IL-8, IL-9, IL-12]. PMID: 25393692
  20. Taken together, these findings indicate that inhibiting IL-4-induced eotaxin-1 expression by synephrine occurs primarily through the suppression of eosinophil recruitment, which is mediated by inhibiting STAT6 phosphorylation. PMID: 25111027
  21. eotaxin-1 increases MMP-3 expression via the CCR3-ERK pathway, thereby promoting prostate cancer cell invasion and migration. PMID: 24604010
  22. the CCL11 GG genotype is a significant risk factor for ischemic as well as hemorrhagic stroke. Further, the frequency of the GG genotype was observed to be higher in hemorrhagic stroke patients in comparison with ischemic stroke. PMID: 25237944
  23. CCL11 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus. PMID: 12949249
  24. thi is a study of the interaction between vCCI and eotaxin-1 (CCL11), a CC chemokine that is an important factor in the asthma response. PMID: 24482230
  25. Cannabis use was found to increase CCL11 plasma levels and the effects were reversed when cannabis use ceases. PMID: 23820464
  26. CCL11, CCL24, and CCL26 are increased in TB patients; hence, it seems that TB suppresses Th1 and the classic function of macrophages subsequently by inducing the chemokines' expression PMID: 24600981
  27. CCL11, CCL24, and CCL26 has a role in the recruitment of extravillous trophoblast into decidual tissue and vessels. PMID: 23477905
  28. CCL11 contributes to eosinophil recruitment in UC and that intestinal myeloid cells are a source of CCL11. PMID: 23904440
  29. These data uncover a previously unknown role for NRF2 in regulating Eotaxin-1 expression and further the mechanistic understanding of this pathway in modulating inflammatory lung disease. PMID: 23061798
  30. The impact of three single-nucleotide polymorphisms in eotaxin (SCYA11) gene promoter (-426C>T and -384A>G) and first exon (67G>A) and recently described hexanucleotide (GAAGGA)(n) 10.9 kb upstream on coronary atherosclerosis was investigated. PMID: 22773402
  31. Serum levels for CCL1 (I-309) were significantly elevated among all men with enlarged prostates (P < 0.04). Serum levels for CCL11 (Eotaxin-1) were significantly elevated among men with prostate cancer regardless of prostate size (P < 0.01). PMID: 23059958
  32. The Marfan syndrome patients with lowest mental quality of life and vitality scores had high levels of CCL11 cytokine. PMID: 23049769
  33. Study found that the plasma concentration of eotaxin was associated with the clinical severity of chronic rhinosinusitis in Taiwanese patients. PMID: 22271279
  34. The level of eotaxin expression and inflammatory cell count were measured in the material from nasal brushing in healthy controls and in patients with allergic rhinitis, asthma, and chronic obstructive pulmonary disease. PMID: 22846146
  35. the eotaxin/CCL11-CCR3 axis is active in idiopathic retroperitoneal fibrosis (IRF) and may contribute to its pathogenesis; the TTCCAT haplotype within the CCL11 gene is significantly associated with IRF PMID: 23114905
  36. Serum CCL17, IL-8, and eotaxin levels were significantly increased in eosinophilic subjects as compared to normal controls, but were similar between Churg-syndrome and hypereosinophilic syndrome. PMID: 22775568
  37. Eotaxin-1 not only induces MMP-3 gene expression but also promotes MMP-3 protein secretion through G protein-coupled eotaxin-1 receptor activities. PMID: 22114952
  38. Pretreated CCD-11Lu cells with noncytotoxic doses (0.1-10 muM) of CAPE inhibited the production of eotaxin under stimulation of IL-4 and tnf-alpha.CAPE pretreatment decreased the amount of pSTAT6 and STAT6 DNA binding complexes in nuclear extracts. PMID: 21601544
  39. In this study, eotaxin-1 -384 A>G or 67 G>A genotypes were not associated with susceptibility to Nasal Polyposis. PMID: 21825098
  40. Data show that expression levels of CCL11 and CCR3 mRNA in the lesional skin of ALCL were significantly higher than those in normal skin. PMID: 21406396
  41. After corticosteroid therapy, the expressions of Eotaxin and Eotaxin-2 in mucosal epithelia of nasal polyps were significantly decreased. PMID: 19522186
  42. Eotaxin induces proliferation of nonasthmatic airway smooth muscle cells and decreases their rate of apoptosis. PMID: 21368236
  43. The expression of Eotaxin-1 and -2 in nasal polyposis and polyps was dramatically higher than in controls. PMID: 17438849
  44. Corticosteroid treatment of nasal polyps reduced expression of CCL11. PMID: 17438850
  45. Measurements of eotaxin-1 in exhaled breath condensate of asthma patients may provide a useful diagnostic tool for detecting and monitoring airway inflammation and disease severity. PMID: 20704746
  46. Serum CCL18 level was significantly decreased in epithelial ovarian cancer patients with early stages compared to those with late stages. PMID: 19937162
  47. elevated levels of eotaxin in children with stable asthma; correlation with eosinophilia PMID: 20444156
  48. Eotaxin may up-regulate the expression of VCAM-1 in vessel endothelium and promote adhesion and migration of eosinophils, as a result, to lead to the recurrence of nasal polyps. PMID: 16874958
  49. Serum CCL11 was increased in ulcerative colitis (UC) and less in Crohn's disease (CD), whereas CCL24 and CCL26 were increased only in UC. Colon expression of the CCL's was higher in UC vs. CD, and was induced by Th2 cytokines in colon epithelial cells. PMID: 21077277
  50. SOCS1 and 3 may control chemotaxis and adhesion PMID: 20934424
  51. genetic variants, including Ala/Ala of SCYA11 (eotaxin) Ala23Thr, Cys/Cys or Cys/Ser of PON2 (paraoxonase 2) Ser311Cys and Arg/Arg of ADRB3 (beta3-adrenergic receptor) Trp64Arg, were independently associated with incident cardiac end-point. PMID: 20536507
  52. interaction of eotaxins and CCR3 regulates the Th2-dominant tumor environment, which is closely related to the development of cutaneous T-cell lymphoma PMID: 20505746
  53. The mean gene expression level for CCL11, CCL24, CCL26 was higher in skin changes of atopic dermatitis patients than in uninvolved skin. PMID: 20236835
  54. IL-4 induces eotaxin in ectopic endometrial stromal cells, which might promote angiogenesis and subsequent development of endometriosis. PMID: 19338989
  55. Circulating endothleial progenitor cells of asthmatic patients had higher levels of eotaxin-1 compared with those seen in control subjects. PMID: 20227754
  56. Data show that both plasma eotaxin level and expression of CCR3 on CD4+ T cells were higher in allergic patients than controls in different types of allergy. PMID: 20306659
  57. Eotaxin/CCL11 may down-regulate production of the neutrophil chemoattractant IL-8/CXCL8 by vascular endothelial cells in vivo, acting as a negative regulator of neutrophil recruitment. PMID: 11884459
  58. Expression of eotaxin parallels eosinophil accumulation in the vesiculobullous stage of incontinentia pigmenti PMID: 11966763
  59. bronchial expression increased in exacerbated chronic bronchitis PMID: 11991282
  60. Histamine and serotonin stimulate eotaxin and augment the expression of eotaxin mRNA production by a human lung fibroblast cell line. PMID: 12065904
  61. Pretreatment or co-treatment with each of the eotaxins augmented PMAtate-induced superoxide generation, concentration-dependent degranulation of eosinophil peroxidase, & potentiation of A23187-induced degranulation. PMID: 12192108
  62. Intradermal injection of CCL11 induces recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions in atopic and nonatopic volunteers. PMID: 12193745
  63. Eotaxin-1 protein and mRNA are synergistically up-regulated in airway fibroblasts from asthmatic and normal subjects by TGF-beta 1 and IL-13 in combination. PMID: 12370400
  64. Infiltrating eosinophils that express eotaxin and the changes of blood eotaxin levels during steroid therapy suggest that eotaxin may be associated with idiopathic eosinohilic esophagitis PMID: 12392390
  65. results suggest that expression of chemokine receptor 3(CCR3) and its ligand eotaxin/CCL11 plays a role in the recruitment and retention of CD30(+) malignant T cells to the skin PMID: 12393570
  66. eosinophil responses mediated by chemokines acting at CCR3 may be regulated by two distinct mechanisms: the antagonistic effects of CXCR3 ligands and the sequestration of CCL11 by CXCR3-expressing cells PMID: 12884299
  67. IL-5 and eotaxin are associated with acute exacerbation of asthma. PMID: 12915771
  68. Production of Eotaxin by eosinophils already within nasal polyps is likely an important mecahanism by which even more eosinophils may be recruited into the polyp tissue. PMID: 12916705
  69. High local levels of eotaxin as present in the blister fluid correspond to the high state of activation of the infiltrated eosinophils in tissue eosinophilia in pemphigoid gestationis PMID: 14725564
  70. the two N-terminal motifs of eotaxin must cooperate with other regions to successfully bind and activate CCR3 PMID: 14733956
  71. Our results suggest that the polymorphisms of the eotaxin gene family are associated with the susceptibility of asthma and Eotaxin-3 might play the critical role for the recruitment of eosinophils and the maintenance of IgE levels. PMID: 15207712
  72. Asthmatics who were vaccinated with a single dose of influenza subunit vaccine showed elevated eotaxin seum levesls. PMID: 15223611
  73. Results show that human chondrocytes express eotaxin-1, that its expression is induced by treatment with interleukin-1beta and TNF-alpha, and suggest that it plays an important role in cartilage degradation in osteoarthritis. PMID: 15389872
  74. Single nucleotide polymorphisms at the CCL11 locus is an important determinant of serum total IgE levels among patients with asthma. PMID: 16461130
  75. Eotaxin (CCL11) is a CC chemokine, whose systemic levels might be associated with coronary artery disease (CAD) and genetic variants predispose to the myocardial infarction (MI). PMID: 16510147
  76. serum expression of eotaxin & IL-5 were significantly increased in patients with strongyloidiasis compared with controls; this rise suggests that selective mediators of the eosinophil can have a role in immunity against S. stercoralis in human infection PMID: 16879311
  77. A highly significant association of the newly studied (GAAGGA)(n) hexanucleotide repeat with asthma (p = 3x10(-6)), log(10)TsIgE (p = 0.006) and eotaxin levels (p = 0.004) was observed. PMID: 17220216
  78. The Th2 cytokine IL-4 preferentially stimulated eotaxin expression. IL-4 activated the eotaxin promoter and STAT6 binding to it. PMID: 17541284
  79. A significant correlation exists between bronchoalveolar lavage concentration of CCL11 and eosinophils in veterans with sulfur mustard gas-induced pulmonary fibrosis. PMID: 17620002
  80. Eotaxin-1 protein levels in colorectal tumours were significantly (P < 0.0001) higher than in normal tissue PMID: 17672898
  81. There were significantly greater concentrations of the chemokines CCL3 and CCL11 in plasma of leprosy patients than in non-infected individuals PMID: 17827376
  82. This study finding provide a strong evidence that Eotaxin 1 Thr23Thr homozygote has a protective effect on asthma and significantly decreases plasma Eotaxin 1 concentrations in asthmatics in Taiwan. PMID: 17845580
  83. Developing lung expresses the eotaxins and functional CCR3 receptor. PMID: 18055844
  84. Results suggest that dexamethasone, depending on the exposure duration, can either inhibit or enhance IL-4-induced expression and production of eotaxin in lung fibroblasts. PMID: 18203973
  85. the eotaxin gene may play a crucial role in the development of extrinsic Atopic Dermatitis, probably with other genetic factors. PMID: 18312459
  86. This study raises the hypothesis that high serum levels of eotaxin predict less radiographic progression in early RA patients. PMID: 18312691
  87. Gram-negative bacteria inhibited the release of eotaxin-1 from human airway smooth muscle cells. PMID: 18380907
  88. except for IL-6 and eotaxin, CLL B-cells and their normal counterparts produce and secrete similar amounts of cytokines and cytokine receptors in vitro. PMID: 18398743
  89. In a collagen matrix three-dimensional model, CCL11-induced eosinophil migration is fully dependent on both RhoA GTP-binding protein and Rho-associated protein kinase (ROCK). PMID: 18523302
  90. CCL11 mediates airway smooth muscle migration PMID: 18699931
  91. Eotaxin-1, Eotaxin-2 and Eotaxin-3 gene polymorphisms and gene-gene interactions among them are associated with the development of asthma. PMID: 18712274
  92. Gene expression of eotaxin-1/CCL11 showed relevant downregulation in four cases and a modest twofold decrease in three of the patients studied with EE treated with topical steroids. PMID: 18844613
  93. activation of prostanoid thromboxane A(2) receptors in a Th2-dominant microenvironment might exacerbate the eosinophilic inflammation of the airways by synthesis and release of CCL11 from bronchial smooth muscle cells PMID: 18950617
  94. CCL11 induces SOCS1 and SOCS3 expression in murine macrophages, human monocytes, and dendritic cells and inhibits GM-CSF-mediated STAT5 activation and IL-4-induced STAT6 activation in a range of hematopoietic cells. PMID: 18971287
  95. intestinal macrophage and epithelial cell-derived eotaxin-1 plays a critical role in the regulation of eosinophil recruitment in colonic eosinophilic disease such as pediatric ulcerative colitis PMID: 18981162
  96. CCL11 signaling plays an important role in proliferation and invasion of ovarian carcinoma cells and CCL11 pathway could be targeted for therapy in ovarian cancer. PMID: 19351767
  97. IL-2 and eotaxin-1 levels may be important markers of disease stability in chronic obstructive pulmonary disease. PMID: 19925666

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Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Database Links

HGNC: 10610

OMIM: 601156

KEGG: hsa:6356

STRING: 9606.ENSP00000302234

UniGene: Hs.54460

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