CCL11

CCL11, C-C motif chemokine ligand 11, also known as Eotaxin-1, is a small inducible cytokine and a member of the C-C motif chemokine family. It plays a key role in the migration and activation of a wide range of immune cells, and is particularly strong chemoattractant for eosinophils, basophils, and Th2 lymphocytes.CCL11 acts by binding to chemokine receptors such as CCR2, CCR3, and CCR5, with CCR3 being the primary receptor mediating the biological effects of CCL11.

CCL11 is involved in a a variety of physiological and pathological processes, including eosinophil homing in asthma, recruitment of immune cells in the tumour microenvironment, and a potential role in aging and neurodegenerative diseases. Studies have shown that CCL11 expression is upregulated in older adults and is associated with the development of certain age-related diseases. In addition, CCL11 expression has been linked to immunomodulation of the tumour microenvironment, which may influence tumour progression and patient prognosis.