CCL11, C-C motif chemokine ligand 11, also known as Eotaxin-1, is a small inducible cytokine and a member of the C-C motif chemokine family. It plays a key role in the migration and activation of a wide range of immune cells, and is particularly strong chemoattractant for eosinophils, basophils, and Th2 lymphocytes.CCL11 acts by binding to chemokine receptors such as CCR2, CCR3, and CCR5, with CCR3 being the primary receptor mediating the biological effects of CCL11.
CCL11 is involved in a a variety of physiological and pathological processes, including eosinophil homing in asthma, recruitment of immune cells in the tumour microenvironment, and a potential role in aging and neurodegenerative diseases. Studies have shown that CCL11 expression is upregulated in older adults and is associated with the development of certain age-related diseases. In addition, CCL11 expression has been linked to immunomodulation of the tumour microenvironment, which may influence tumour progression and patient prognosis.
CCL11 Antibody (CSB-PA004775ESR2HU)
Validated Data
Western blot
All lanes: CCL11 antibody at 5μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 11 kDa
Observed band size: 11 kDa
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA004775ESR2HU at dilution of 1:100
Rat Eotaxin 1 (Eotaxin 1/CCL11/ECF)ELISA Kit (CSB-E07319r)
Validated Data
Code: CSB-E07319r
Size: 96T,5×96T,10×96T
Sensitivity: 3.9 pg/ml
Detection Range: 15.6 pg/ml -1000 pg/ml
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following CCL11 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CCL11 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004775GA01HU | CCL11 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA004775ESR2HU | CCL11 Antibody | Human | ELISA, WB, IHC |
CSB-PA005780 | CCL11 Antibody | Human,Mouse,Rat | WB, ELISA |
CCL11 Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP004775GU CSB-EP004775GU CSB-BP004775GU CSB-MP004775GU CSB-EP004775GU-B |
Recombinant Guinea pig Eotaxin (CCL11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL11 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP004775RA CSB-EP004775RA CSB-BP004775RA CSB-MP004775RA CSB-EP004775RA-B |
Recombinant Rat Eotaxin (Ccl11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP001561RA | Recombinant Rat Eotaxin protein (Ccl11) (Active) | E.coli |
CCL11 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP004775MO CSB-EP004775MO CSB-BP004775MO CSB-MP004775MO CSB-EP004775MO-B |
Recombinant Mouse Eotaxin (Ccl11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP001291MO | Recombinant Mouse Eotaxin protein (Ccl11) (Active) | E.coli |
CCL11 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP004775HU CSB-BP004775HU CSB-MP004775HU CSB-EP004775HU-B |
Recombinant Human Eotaxin (CCL11) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP000901HU | Recombinant Human Eotaxin protein (CCL11) (Active) | E.coli |
CSB-EP004775HU | Recombinant Human Eotaxin (CCL11) | E.coli |
CCL11 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP850742MOW CSB-EP850742MOW CSB-BP850742MOW CSB-MP850742MOW CSB-EP850742MOW-B |
Recombinant Macaca mulatta Eotaxin (CCL11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP001041MOW | Recombinant Rhesus Macaque Eotaxin protein (CCL11) | E.Coli |
CCL11 Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP890591HO CSB-EP890591HO CSB-BP890591HO CSB-MP890591HO CSB-EP890591HO-B |
Recombinant Horse Eotaxin (CCL11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL11 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP890592BO CSB-EP890592BO CSB-BP890592BO CSB-MP890592BO CSB-EP890592BO-B |
Recombinant Bovine Eotaxin (CCL11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL11 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04533h | Human eosinophil chemotactic factor,ECF ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 7.8 pg/mL |
CCL11 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07319r | Rat Eotaxin 1 (Eotaxin 1/CCL11/ECF)ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/ml |