Recombinant Mouse C-C motif chemokine 25 protein(Ccl25) (Active)

In Stock
Code CSB-AP001371MO
Product Type Chemokine
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. O35903
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Chemokine TECK, Thymus-expressed chemokine
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 5.0-50 ng/ml.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence QGAFEDCCLG YQHRIKWNVL RHARNYHQQE VSGSCNLRAV RFYFRQKVVC GNPEDMNVKR AIRILTARKR LVHWKSASDS QTERKKSNHM KSKVENPNST SVRSATLGHP RMVMMPRKTN N
Research Area Immunology
Source E.coli
Gene Names Ccl25
Expression Region 24-144aa
Tag Info Tag-Free
Mol. Weight 14.1 kDa
Protein Description Full Length of Mature Protein
PubMed ID 9285413; 10602049; 16517733; 16141072; 19468303; 15489334
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Function Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
Database Links

KEGG: mmu:20300

STRING: 10090.ENSMUSP00000024004

UniGene: Mm.7275

Pathway Chemokine signaling pathway

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