Recombinant Rat Growth-regulated alpha protein (Cxcl1) (Active)

1. The results showed that after short-term incubation both CXCL1 and CXCL2 can activate TRPV1+/IB4+ DRG neurons by significantly reducing TRPV1 desensitization, while at acute application both chemokines induced an increase in [Ca2+]i although of different amplitudes, in a subset of neurons partially also itch-sensitive in the case of CXCL1, or non-itch sensitive in the case of CXCL2. PMID: 28820395
2. remote ischemic preconditioning protects hepatic microcirculation by induction of HO and modulation of cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury PMID: 27672274
3. Results results demonstrate that sphingosine-1-phosphate induces Ca(2+) signaling in astrocytes via Gq -coupled receptors S1P2 and S1P3 , followed by Ca(2+) influx through TRPC6 that could activate MAPK signaling, which leads to increased secretion of the proinflammatory or neuroprotective chemokine CXCL1 PMID: 28300348
4. aging can reduce the expression of CINC and MCP-1 mRNA in lung tissues, and reduce the infiltration of neutrophils and monocyte-macrophages induced by CINC and MCP-1. This might lead to increased risk of pneumonia in elderly patients. PMID: 24464584
5. In opioid-tolerant rats, CXCL1 is up-regulated in CSF; as it is in patients also. PMID: 25383568
6. Function of the transient receptor potential vanilloid (TRPV)1 channel is enhanced by dorsal root ganglia inflammation. The effects (decreased tachyphylaxis) are mimicked by incubation with GRO/KC. PMID: 22466126
7. CXCL1 inhibition of oligodendrocyte progenitor cell migration is regulated via changes in intracellular calcium flux. PMID: 22554866
8. hyperoxia exposure led to a suppression of the HDAC1/HDAC2 expression and activity, and the overall HDAC activity, as well as arrest of alveolarization, and an elevated expression of CINC-1 in the lungs of newborn rats PMID: 21905265
9. Advanced glycation end products promote the secretion of MCP-1 and IL-8 in vascular smooth muscle cells. PMID: 21418993
10. Severe burn injury activates pulmonary NF-kappaB and leads to secretion of IL8 and TNF alpha in the lung. PMID: 17959522
11. In rats with chronic nonbacterial prostatitis, the levels of TNF-alpha and IL-8 in the serum and prostate tissues were significantly lower in the curcumin-treated group than in the positive control group. PMID: 20180411
12. ATP-stimulated C6 glioma cells showed enhanced expression of MCP-1 & IL-8; elevated levels of MCP-1 & IL-8 are predicted to enhance mobility of tumor cells & promote recruitment of microglia into developing tumors thereby supporting tumor growth. PMID: 20003523
13. These results suggest that IL-6 and CINC-1 contribute to alpha2M production in rats only when IL-6 and CINC-1 act synergistically. PMID: 21030786
14. The decreased serum concentration of CINC-1 as neuroprotective agent and increased CINC-2alpha in late stage of Morris hepatoma may be considered for their contribution to cerebellar degeneration. PMID: 20602290
15. Rats treated with fullerenes showed a transient significant increase of neutrophils and expression of CINC-1,-2alphabeta and -3. PMID: 20226088
16. CINC-1, released at sites of inflammation, mediates inflammatory hyperalgesia in rats via release of sympathomimetic amines. PMID: 12517731
17. CINC-1 also functions as an early acute-phase protein after injury to the brain or to peripheral tissues PMID: 12709409
18. neutrophil migration induced by IL-8 is dependent on CINC-1 release from mast cells PMID: 12824006
19. Data show that TII alveolar epithelial cells produce three of the major proinflammatory CXC chemokines (GRO, CINC-2alpha, and MIP-2) and their cognate receptor CXCR2. PMID: 12829448
20. CINC, in contrast to MIP-2, is selectively transported from the lung to the systemic circulation, where it promotes neutrophil migration into the lung in response to a chemotactic stimulus. PMID: 14617513
21. reactive oxygen species and lipid peroxidation mainly derived from neutrophils, which are stimulated and mobilized by TNF-alpha and cytokine-induced neutrophil chemoattractant-1 PMID: 15942680
22. CINC-1 may contribute to liver repair and regeneration PMID: 16271365
23. In summary, hyperalgesia, local PGE2 production, and spinal c-Fos expression occur after CFA-induced inflammation but not after CXCL1- or CXCL2/3-induced, selective PMN recruitment. PMID: 16522746
24. results demonstrate that ascorbic acid deficiency elevates the serum, liver and spleen concentrations of cytokine-induced neutrophil chemoattractant-1 (CINC-1 as seen in acute inflammation PMID: 16637227
25. Following cecal ligation and puncture CINC-1 production increases in the lung, setting the stage for neutrophil accumulation in lung during sepsis. PMID: 16818791
26. activation of PAR-2, as well as PAR-1, can rescue astrocytes from ceramide-induced apoptosis via regulating chemokine GRO/CINC-1 release. PMID: 16942465
27. berberine dose-dependently inhibited the expression of CINC-1 induced by LPS and diminished the anterior uveitis. PMID: 17164575
28. TNFalpha has in different forms of arthritis, but points out the idea that CINC-1 (the homologue for human IL-8) may constitute a promising target for reactive arthritis management PMID: 17166735
29. basal level of calcium is the pre-requisite for GRO/CINC-1 protein synthesis and secretion PMID: 17666044
30. Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells. PMID: 17702850
31. GGA effectively suppressed the up-regulation of GRO1 messenger ribonucleic acid, and this was validated by Northern hybridization. PMID: 18683011
32. This is the first time that centrally injected CINC-1 has been reported to act directly on the pyrogen-sensitive neurons of the preoptic area, promoting a thermoregulatory response that seems to depend on other endogenous pyrogens synthesis and PGE2. PMID: 18694739
33. CXCL1 incubation (1.5 nM, overnight) caused marked upregulation of Na+ currents in acutely isolated small diameter rat (adult) sensory neurons in vitro. PMID: 18816377
34. The results suggest that GRO/KC has important effects in inflammatory processes via its direct actions on sensory neurons. PMID: 19476648
35. CINC-1 is a neutrophil chemoattractant; findings have established that CINC-1 also functions as an early acute-phase protein after injury to the brain or to peripheral tissues. PMID: 12709409

Show More

Hide All

KEGG: rno:81503

STRING: 10116.ENSRNOP00000003778

UniGene: Rn.10907