CXCL1

CXCL1, also known as C-X-C motif chemokine 1, is commonly referred to as GRO-α, MGSA-α. This protein plays a crucial role in the immune response. It functions by binding to CXCR2 receptors on target cells, recruiting neutrophils to sites of inflammation. It is involved in the MAPK and NF-κB signaling pathways, which regulate cell proliferation and survival.
CXCL1 is associated with various diseases, including cancer and inflammatory disorders. In cancer, it promotes tumor growth, angiogenesis, and metastasis. Researchers are exploring drugs that target CXCL1 or its receptors to develop new therapies for these diseases, aiming to block its signaling and control related pathological processes.