Recombinant Rhesus Macaque Granulocyte-macrophage colony-stimulating factor protein (GM-CSF) (Active)

GM-CSF is a critical hematopoietic cytokine that drives granulocyte and macrophage proliferation, differentiation, and activation through JAK2/STAT5 and MAPK signaling cascades. This tag-free recombinant rhesus macaque GM-CSF, encompassing the full-length mature sequence (18–144 aa), demonstrates exceptional signaling potency with an ED50 below 0.1 ng/ml in TF-1 cell proliferation assays, corresponding to a specific activity exceeding 1.0 × 10⁷ IU/mg — providing a reliable reference standard for cytokine detection assays and a robust positive control for dose-response studies. The species-matched sequence supports use in nonhuman primate in vivo models of inflammation, infection, and tumor biology, while also serving as an effective immunogen or coating antigen for antibody development and validation workflows. Endotoxin levels below 1.0 EU/μg minimize LPS-driven artifacts in sensitive immune cell functional assays, and purity exceeding 98% by SDS-PAGE satisfies the stringent criteria expected for JAK/STAT pathway activation studies and myeloid differentiation experiments.