ABCC1 Antibody

Code CSB-PA866392XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) ABCC1 Polyclonal antibody
Uniprot No.
Target Names
ABCC1
Alternative Names
ABCC1 antibody; EST1 antibody; MRP1 antibody; At1g30400 antibody; T4K22.12ABC transporter C family member 1 antibody; ABC transporter ABCC.1 antibody; AtABCC1 antibody; EC 7.6.2.2 antibody; ATP-energized glutathione S-conjugate pump 1 antibody; Glutathione S-conjugate-transporting ATPase 1 antibody; Multidrug resistance-associated protein 1 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana ABCC1 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Pump for glutathione S-conjugates. Mediates the transport of S-(2,4-dinitrophenyl)-glutathione (DNP-GS), GSSG, cyanidin 3-glucoside-GS (C3G-GS) and metolachlor-GS (MOC-GS).
Gene References into Functions
  1. Data indicate that phosphorylation of serine Ser846 is required for the arsenic (As) resistance function of ATP-Binding Cassette (ABC) transporter ABCC1 (AtABCC1). PMID: 28130831
  2. MRP1 is important for vacuolar accumulation of antifolates as well as tolerance against arsenic, both of which involved phosphorylation in the serine triads at the C terminal nucleotide binding domain of MRP1. PMID: 27428365
  3. atmrp1 knock-out mutants are more sensitive than wild-type plants to growth retardation by nanomolar concentrations of MTX, and this is associated with impaired vacuolar antifolate sequestration. PMID: 19136566
Subcellular Location
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein Families
ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Tissue Specificity
Ubiquitous, with higher levels in leaves and stems and lower levels in roots. Localized in the root apex, root hair tips and root epidermis.
Database Links

KEGG: ath:AT1G30400

STRING: 3702.AT1G30400.1

UniGene: At.21491

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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