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| Code | CSB-PA370646XA01DIL |
| Product Type | Polyclonal Antibody |
| Uniprot No. | A0MTA1 |
| Delivery | Make-to-order |
| Immunogen | Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) APEX1 protein |
| Raised in | Rabbit |
| Species Reactivity | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Form | Liquid |
| Conjugate | Non-conjugate |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method | Protein A/G |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (zAP1) apex1 apex1a apex1b si:ch211-214j24.12 zgc:66204 |
| Immunogen Species | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Protocols | ELISA Protocol |
| Gene Names | apex1 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Function as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Required for passage through the midblastula transition MBT. May also act as an endoribonuclease involved in the control of single-stranded RNA metabolism. Has no redox activity. Binds DNA and RNA. |
| Subcellular Location | Nucleus, Nucleus, nucleolus, Nucleus speckle, Endoplasmic reticulum, Cytoplasm, Mitochondrion |
| Protein Families | DNA repair enzymes AP/ExoA family |
| Database Links |
STRING: 7955.ENSDARP00000067373 UniGene: Dr.20170 |
| Pathway | DNA repair pathway |
apex1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP370646DIL CSB-EP370646DIL CSB-BP370646DIL CSB-MP370646DIL |
Recombinant Danio rerio DNA-(apurinic or apyrimidinic site) lyase | Yeast E.coli Baculovirus Mammalian cell |
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