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| Code | CSB-PA370646XA01DIL |
| Size | Pls inquire |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) apex1 Polyclonal antibody |
| Uniprot No. | A0MTA1 |
| Target Names | apex1 |
| Alternative Names | apex1 antibody; apex1a antibody; apex1b antibody; si:ch211-214j24.12 antibody; zgc:66204DNA-(apurinic or apyrimidinic site) lyase antibody; EC 3.1.-.- antibody; EC 4.2.99.18 antibody; APEX nuclease antibody; APEN antibody; Apurinic-apyrimidinic endonuclease 1 antibody; AP endonuclease 1 antibody; zAP1 antibody |
| Raised in | Rabbit |
| Species Reactivity | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Immunogen | Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) apex1 protein |
| Immunogen Species | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Conjugate | Non-conjugated |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | Protein A/G |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Value-added Deliverables | ① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control); |
| Quality Guarantee | ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive; |
| Lead Time | Made-to-order (14-16 weeks) |
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| Function (From Uniprot) |
Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Required for passage through the midblastula transition MBT. May also act as an endoribonuclease involved in the control of single-stranded RNA metabolism. Has no redox activity. Binds DNA and RNA. |
| Subcellular Location | Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Mitochondrion. |
| Protein Families | DNA repair enzymes AP/ExoA family |
| Database Links |
STRING: 7955.ENSDARP00000067373 UniGene: Dr.20170 |
