APEX1

DNA-is a protein in humans that is encoded by APEX1 gene. Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules.

APEX1 Antibodies

APEX1 Antibodies for Homo sapiens (Human)

APEX1 Antibodies for Mus musculus (Mouse)

APEX1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

APEX1 Proteins

APEX1 Proteins for Mus musculus (Mouse)

APEX1 Proteins for Bos taurus (Bovine)

APEX1 Proteins for Homo sapiens (Human)

APEX1 Proteins for Rattus norvegicus (Rat)

APEX1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

APEX1 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

APEX1 Proteins for Gorilla gorilla gorilla (Western lowland gorilla)

APEX1 Proteins for Pan troglodytes (Chimpanzee)

APEX1 Proteins for Pongo pygmaeus (Bornean orangutan)

APEX1 ELISA Kit

APEX1 ELISA Kit for Homo sapiens (Human)

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