shg Antibody

1. In disc-proper epithelial cells, DE-cadherin localizes to the zonula adherens, and in puncta at the basal, and lateral sides. Fra overexpression of affects DE-Cadherin distribution and apico-basal cell shape so that there is loss of DE-Cadherin in the basal and lateral regions. PMID: 29518139
2. several phospho-mutations dramatically reduced the biosynthetic turnover rate of DE-Cad during apical-basal polarization. PMID: 28219947
3. Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows PMID: 28296858
4. alpha-Catenin controls actomyosin dynamics by stabilising and promoting the formation of actomyosin foci, and also stabilises DE-Cadherin (Drosophila E-Cadherin, also known as Shotgun) at the cell membrane, suggesting that medioapical actomyosin contractility regulates junction stability. PMID: 27831494
5. In embryos mutant for the FGF signaling pathway components Branchless and Breathless, zygotic E-cadherin is not targeted to adherens junctions, causing midgut pocket collapse. PMID: 26604222
6. These results indicate an active role for E-Cad in mediating cohesive and ordered migration of non-epithelial cells, and discount the notion of E-Cad as just an epithelial feature that has to be switched off to enable migration of mesenchymal cells. PMID: 26272476
7. the sustained E-cadherin-dependent adhesion organizes the microvilli meshwork and ensures the proper attachment of RCs to the PM, thereby counteracting the increasing membrane tension induced by exponential tissue growth. PMID: 26424451
8. Hox coordination of tissue morphogenesis relies on boundary fold formation through the modulation of DE-cad positioning PMID: 26206615
9. The membrane-proximal half of the DE-cadherin extracellular region is dispensable for many developmental events,but it is essential for efficient and robust apical constriction during ventral furrow formation. PMID: 20184661
10. E-cadherin cluster organization in Drosophila embryos.Dynamin-dependent endocytosis targets large clusters of E-cadherin. PMID: 24184100
11. E-cadherin promotes in vivo cell movement by multiple mechanisms, the combination of which orchestrates collective direction sensing. Of particular note, E-cadherin functions at the leading edge in a positive feedback loop with the small GTPase Rac as an integral part of the direction-sensing mechanism. PMID: 24855950
12. E-cadherin is required to maintain Drosophila prohemocyte multipotency and block differentiation. PMID: 24040319
13. findings show that planar polarization of flows emerges from polarized fluctuations in the levels of E-cadherin clusters that produce transient and oscillating asymmetries of coupling; these fluctuations are triggered by polarized E-cadherin endocytosis and are amplified by flow itself PMID: 23871590
14. loss of DE-cadherin strongly enhances the raw mutant gonad phenotype, while increasing DE-cadherin function rescues this phenotype PMID: 22575490
15. findings suggest that Hrp38 and its association with poly(ADP-ribose) control germline stem cell self-renewal and oocyte localization by regulating DE-cadherin translation PMID: 22453833
16. DE-Cad and armadillo in adherens junctions of polarizing epithelial cells had much faster biosynthetic turnover than in polarized cells. PMID: 22159415
17. Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV. PMID: 21389054
18. Jafrac1-mediated reduction of hydrogen peroxide is required to maintain DE-cadherin protein levels in the early embryo. PMID: 21316590
19. The studies demonstrate a novel and crucial role for Pak1 and E-cadherin endocytosis in determining salivary gland lumen size and shape, and also identify a mechanism for multiple lumen formation. PMID: 21068057
20. E-cadherin orchestrates multiple aspects of stem cell behavior PMID: 20824213
21. regulates orientation of asymmetric cell division in the sensory organ lineage PMID: 11818059
22. study demonstrates that anchorage of germline stem cells (GSCs) in their niche by DE-cadherin-mediated adhesion is important for stem cell maintenance and function. PMID: 12052957
23. functions in normal optic placode morphogenesis PMID: 12163402
24. mediates cell adhesion and is essential for maintaining somatic stem cells in the Drosophila ovary PMID: 12393817
25. DE-cadherin plays a pivotal role in larval brain proliferation, brain cortex morphogenesis, and axon growth PMID: 12716940
26. Data show that Drosophila E-cadherin is essential both for germ cell ensheathment and gonad compaction, and is upregulated in the somatic gonad at the time of gonad formation. PMID: 12900457
27. DE-cadherin plays a pivotal role in delamination and polarized division of neuroblasts. PMID: 15183719
28. Elevated transcription of DE-cadherin is sufficient to attract the oocyte to lateral and anterior positions. PMID: 15852002
29. Results describe the requirements for Drosophila melanogaster epithelial (DE) cadherin regulation in vivo. PMID: 16129787
30. regulation of cadherin-based adherens junctions by Rac is critical for salivary gland morphogenesis and that this regulation occurs through dynamin-mediated endocytosis PMID: 16412417
31. zinc is a crucial regulator of developmental processes and can affect DE-cadherin expression on multiple levels PMID: 16481356
32. DE-cadherins integrate input from at least two signaling pathways, resulting in a coordinated cell movement PMID: 16887833
33. While Decapentaplegic (Dpp) acts downstream of Ras to maintain vein cell identity in the pupal wing, these results indicate that Ras controls Shg localization via a Dpp-independent mechanism. PMID: 17888420
34. Uncoupling stability and mobility of E-cadherin complexes suggests that stable epithelia may remodel through the regulated mobility of very stable adhesive foci. PMID: 18480755
35. levels of E-cadherin, an adherens junction component and Rab11-compartment cargo, are dynamically regulated by trafficking during tracheal development PMID: 18641639
36. Overexpressed Armadillo mutants exhibit different levels of activity and stability, but retain E-Cadherin binding. PMID: 18682750
37. Demonstrate that E-cadherin (E-cad) is required for stable attachment between the an intestinal stem cell and a progenitor cell. PMID: 19021776

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KEGG: dme:Dmel_CG3722

STRING: 7227.FBpp0071475