CDC4 Antibody

1. An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF ubiquitin ligase. PMID: 28045046
2. Our observations suggest that both APC(Cdh1) and SCF(Cdc4)-dependent proteolysis of Clb6 at the G1/S border are crucial for multiple cell cycle regulated events including proper expression of Clb2, the G1/S and G2/M cell cycle transitions and for proper completion of cell division at mitotic exit. PMID: 26994663
3. an intricate coordination between Hst3 synthesis, genome-wide H3K56 deacetylation by Hst3, and cell cycle-regulated degradation of Hst3 by cyclin-dependent kinases and SCF(Cdc4). PMID: 24648511
4. we show that Cln3 is redundantly targeted by two F-box proteins with key cell cycle-regulatory roles, Cdc4 and Grr1 PMID: 22844257
5. Individually weak dispersed Sic1 phospho sites engage Cdc4 in a dynamic equilibrium. The multisite nature of this interaction confers cooperative dependence on kinase activity for Sic1 recognition PMID: 22328159
6. analysis of structure/function of a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase PMID: 20399186
7. Data show that high-affinity binding of recombinant Cdc4 to Tec1 phosphopeptides requires phosphorylation of not only T273 but also a second site, T276. PMID: 19897738
8. SCFCdc4 ubiquitin ligase mediate the degradation of Tec1, a cofactor of Ste12 for the expression of filamentation genes, during pheromone response. PMID: 15620356
9. SCF(Cdc4) ubiquitin ligase complex regulates Clb6 turnover PMID: 16508019
10. A model that explains the role of multiple cyclin E/Sic1 degrons is provided by the findings that Fbw7 and Cdc4 dimerize, and that Cdc4 dimerization increases the rate and processivity of Sic1 ubiquitination in vitro. PMID: 17434132
11. the SCFCdc4 dimer suprafacial orientation accommodates multiple geometries for substrate ubiquitination PMID: 17574027
12. SCF(Cdc4)-dependent degradation required phosphorylation of Rcn1 by Mck1 PMID: 17954914
13. findings indicate that the SCF(Cdc4) complex regulates S phase entry not only through degradation of Sic1, but also through degradation of Swi5 PMID: 18787112
14. The observation of this unusual binding mode between Sic1 and Cdc4 extends the understanding of protein interactions from predominantly static complexes to include dynamic ensembles of intrinsically disordered states. PMID: 19008353

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KEGG: sce:YFL009W

STRING: 4932.YFL009W