DKK3 Antibody

Code CSB-PA865568XA01MO
Product Type Polyclonal Antibody
Uniprot No. Q9QUN9
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Mus musculus (Mouse) DKK3 protein
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (mDkk-3) Dkk3
Immunogen Species Mus musculus (Mouse)
Gene Names Dkk3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Subcellular Location Secreted
Protein Families Dickkopf family
Tissue Specificity Highest expression in brain, eye and heart.
Database Links

KEGG: mmu:50781

STRING: 10090.ENSMUSP00000033036

UniGene: Mm.55143

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