Dbi Antibody

Code CSB-PA006519ZA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Dbi Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
DbiAcyl-CoA-binding protein antibody; ACBP antibody; Diazepam-binding inhibitor antibody; DBI antibody; Endozepine antibody; EP) [Cleaved into: Triakontatetraneuropeptide antibody; TTN); Octadecaneuropeptide antibody; ODN)] antibody
Raised in
Species Reactivity
Rattus norvegicus
Recombinant Rattus norvegicus Dbi protein
Immunogen Species
Rattus norvegicus (Rat)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Gene References into Functions
  1. Data suggest that neuroglia play important role in glucose sensing in hypothalamus and may regulate energy balance/appetite control through production/secretion of endozepines (diazepam binding inhibitor and processing product, octadecaneuropeptide). PMID: 23160530
  2. Cerebral DBI mRNA expression significantly increased after conditioned emotional stimuli. Cerebral DBI is enhanced by psychological stress, which is regulated by central BZD receptors. PMID: 12117556
  3. expression of ACBP in rodent hepatocytes is subject to dual metabolic regulation by PPARalpha and SREBP-1c, which may reflect the need for ACBP during lipogenic as well as lipo-oxidative conditions PMID: 15611101
  4. The basal transcription of ACBP is modulated by members of the PPAR and SREBP families PMID: 16411019
  5. ACBP acts as an acyl-CoA pool former in transgenic rats and regulates lipid metabolism via SREBP-1 and PPAR regulation PMID: 18157544
  6. Data suggest that reversible phosphorylation of ACBP regulates its ability to activate calpain in phosphatase inhibitor-induced apoptosis and controls the cellular accessibility of long-chain fatty acid-CoAs for cellular signaling. PMID: 18455725

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Subcellular Location
Endoplasmic reticulum. Golgi apparatus.
Protein Families
ACBP family
Database Links
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