Dsg2 Antibody

1. generated a Dsg2 loss-of-function strain (Dsg2 (lo/lo)) and observed that, in response to reduced levels of Dsg2: (i) CD31(+) endothelial cells in the pancreas are hypertrophic and exhibit altered morphology, (ii) bone marrow-derived endothelial colony formation is impaired, (iii) ex vivo vascular sprouting from aortic rings is reduced, and (iv) vessel formation in vitro and in vivo is attenuated PMID: 27338829
2. Data suggest that loss of desmoglein 2 (Dsg2) compromises adhesion, and that this is a major pathogenic mechanism in DSG2-related and probably other desmosome-related arrhythmogenic cardiomyopathy (AC). PMID: 26085008
3. Dsg2 modulates Gli1 expression. Dsg2-mediated hyperproliferation, MEK/Erk1/2 activation, and accelerated squamous tumor development are enhanced on the Ptc1+/lacZ background. PMID: 25871385
4. a novel pathway of CSTA regulation involving Dsg2 PMID: 25785582
5. Data demonstrate that desmoglein-2 plays a critical role in cardiomyocyte cohesion and function. PMID: 25213555
6. Dsg2 compensates for Dsg3 depletion with regard to cell cohesion, but does not regulate p38 MAPK signaling. PMID: 24782306
7. In vivo interaction between Dsg2 and Na(V)1.5 provides a molecular pathway for the observed electrical disturbances during the early arrhythmogenic right ventricular cardiomyopathy. PMID: 22764152
8. Mutant desmoglein 2 cannot support the increased requirements placed on intercalated disc adhesion during postnatal heart development. This induces cardiomyocyte death, aseptic inflammation and fibrotic replacement. PMID: 22293975
9. ventricular arrhythmias that has been linked to mutations in desmosomal proteins including desmoglein 2 PMID: 21455723
10. Myocyte necrosis underlies progressive myocardial dystrophy in N271S-dsg2-related arrhythmogenic right ventricular cardiomyopathy. PMID: 19635863

Show More

Hide All

KEGG: mmu:13511

STRING: 10090.ENSMUSP00000057096

UniGene: Mm.345891