DSG2

DSG2 (Desmoglein-2) is a cell adhesion protein that belongs to the cadherin family of calcium-binding proteins. It is primarily expressed in epithelial cells, such as those in the skin, heart, lungs, and intestines. The structural features of DSG2 include an extracellular region and a transmembrane domain. The extracellular region contains multiple domains, including several calcium-binding sites, which facilitate interactions between DSG2 and other cell adhesion proteins (such as other DSG proteins or Plakophilin), forming a structure called "desmosomes." These "desmosomal" connections allow epithelial cells to adhere tightly to one another, enhancing the structural stability of tissues and providing strong intercellular adhesion. This is crucial for maintaining tissue integrity and stability, particularly in situations involving external forces such as the beating of the heart or stretching of the skin. DSG2's role is pivotal in providing tissues with resilience. Abnormalities in DSG2 function may contribute to certain diseases. For instance, certain genetic skin disorders and heart diseases have been associated with mutations or abnormal expression of DSG2.

More Interesting read related DSG2:a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors!

Popular Product

● DSG2 Recombinant Monoclonal Antibody CSB-RA622752MA1HU

Validated Data

ELISA

The Binding Activity of DSG2 with anti-DSG2 antibody

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 (CSB-MP622752HU) at 2 μg/mL can bind Anti-DSG2 recombinant antibody，the EC₅₀ is 20.26-38.00 ng/mL

● Recombinant Human Desmoglein-2(DSG2),partial (Active) CSB-MP622752HU

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 at 2μg/mL can bind Anti-DSG2 recombinant antibody (CSB-RA622752MA1HU)， the EC₅₀ is 20.26-38.00 ng/mL