DSG2 (Desmoglein-2) is a cell adhesion protein that belongs to the cadherin family of calcium-binding proteins. It is primarily expressed in epithelial cells, such as those in the skin, heart, lungs, and intestines. The structural features of DSG2 include an extracellular region and a transmembrane domain. The extracellular region contains multiple domains, including several calcium-binding sites, which facilitate interactions between DSG2 and other cell adhesion proteins (such as other DSG proteins or Plakophilin), forming a structure called "desmosomes." These "desmosomal" connections allow epithelial cells to adhere tightly to one another, enhancing the structural stability of tissues and providing strong intercellular adhesion. This is crucial for maintaining tissue integrity and stability, particularly in situations involving external forces such as the beating of the heart or stretching of the skin. DSG2's role is pivotal in providing tissues with resilience. Abnormalities in DSG2 function may contribute to certain diseases. For instance, certain genetic skin disorders and heart diseases have been associated with mutations or abnormal expression of DSG2.
● DSG2 Recombinant Monoclonal Antibody CSB-RA622752MA1HU
Validated Data
The Binding Activity of DSG2 with anti-DSG2 antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 (CSB-MP622752HU) at 2 μg/mL can bind Anti-DSG2 recombinant antibody,the EC50 is 20.26-38.00 ng/mL
● Recombinant Human Desmoglein-2(DSG2),partial (Active) CSB-MP622752HU
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 at 2μg/mL can bind Anti-DSG2 recombinant antibody (CSB-RA622752MA1HU), the EC50 is 20.26-38.00 ng/mL
The following DSG2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
DSG2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA007204GA01HU | DSG2 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA007839 | DSG2 Antibody |
Human | WB, ELISA |
CSB-PA025645 | DSG2 Antibody |
Human | ELISA,IHC |
CSB-PA401715 | DSG2 Antibody |
Human | ELISA,IHC |
CSB-PA622752LA01HU | DSG2 Antibody |
Human | ELISA, IHC, IF |
CSB-PA622752LB01HU | DSG2 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA622752LC01HU | DSG2 Antibody, FITC conjugated |
Human | |
CSB-PA622752LD01HU | DSG2 Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA622752MA1HU | DSG2 Recombinant Monoclonal Antibody |
Human | ELISA |
DSG2 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA007204ZA01MO | Dsg2 Antibody |
Mus musculus | ELISA, WB (ensure identification of antigen) |
DSG2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP007204MO CSB-BP007204MO CSB-MP007204MO CSB-EP007204MO-B |
Recombinant Mouse Desmoglein-2 (Dsg2), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP007204MO | Recombinant Mouse Desmoglein-2 (Dsg2), partial |
E.coli |
DSG2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP622752HU CSB-EP622752HU CSB-MP622752HU CSB-EP622752HU-B |
Recombinant Human Desmoglein-2 (DSG2), partial |
Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP622752HUb1 | Recombinant Human Desmoglein-2 (DSG2), partial |
E.coli |
CSB-BP622752HU | Recombinant Human Desmoglein-2 (DSG2), partial |
Baculovirus |
CSB-EP622752HUa0 | Recombinant Human Desmoglein-2 (DSG2), partial |
E.coli |
CSB-EP622752HUb0 | Recombinant Human Desmoglein-2 (DSG2), partial |
E.coli |
CSB-MP622752HU | Recombinant Human Desmoglein-2 (DSG2), partial (Active) |
Mammalian cell |