ERFE Antibody

Datasheet

Code	CSB-PA677939ZA01HU
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ERFE Polyclonal antibody

Uniprot No.

Q4G0M1

Target Names

ERFE

Alternative Names

Erythroferrone (Complement C1q tumor necrosis factor-related protein 15) (Myonectin), ERFE, C1QTNF15 CTRP15 FAM132B

Raised in

Rabbit

Species Reactivity

Homo sapiens

Immunogen

Recombinant Homo sapiens ERFE protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugate

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

Customer Reviews and Q&A

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Target Background

Function

Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake.

Gene References into Functions

From a clinical point of view, erythroferrone could become a useful biological marker of iron metabolism and a therapeutic target. [review] PMID: 28666715
FAM132b expression is upregulated in Congenital Dyserythropoietic Anemia type II. PMID: 27540014
In hemodialysis patients DA and CERA increased levels of ERFE that regulated hepcidin 25 and led to iron mobilization from body stores during erythropoiesis. PMID: 26978524
Myonectin links skeletal muscle to lipid homeostasis in liver and adipose tissue in response to alterations in energy state, revealing a novel myonectin-mediated metabolic circuit. PMID: 22351773

Subcellular Location

Secreted.

Protein Families

Adipolin/erythroferrone family

Database Links

HGNC: 26727

OMIM: 615099

KEGG: hsa:151176

UniGene: Hs.24951

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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ERFE Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background