GUCY1A2 Antibody

Code CSB-PA010049ZA01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) GUCY1A2 Polyclonal antibody
Uniprot No. P33402
Target Names GUCY1A2
Alternative Names Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2), GUCY1A2, GUC1A2 GUCSA2
Raised in Rabbit
Species Reactivity Homo sapiens
Immunogen Recombinant Homo sapiens GUCY1A2 protein
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugate
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

Function
(From Uniprot)
Has guanylyl cyclase on binding to the beta-1 subunit.; Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.
Gene References into Functions
  1. The data support a novel regulatory mechanism whereby sGC activity is tuned by distinct domain interactions that either promote or inhibit catalytic activity. PMID: 24669844
  2. The CO binding affinity of soluble guanylate cyclase alpha 2 subunit is threefold greater than that of human soluble guanylate cyclase alpha 1 subunit. PMID: 22426988
  3. The sGC alpha 1observed in OVCAR-3 and MDA-MB-468 cancer cells which correlated well with the sGC activity and a marked increase in cGMP levels upon exposure to the combination of a NO donor and a sGC activator. PMID: 19948239
  4. Soluble guanylyl cyclase (sGC) is the major cellular receptor for the intercellular messenger nitric oxide (NO) and mediates a wide range of physiological effects through elevation of intracellular cGMP levels PMID: 11752394
  5. No significant changes were found in sGC subunit mRNAs in people with schizophrenia or in controls. PMID: 15094474

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Subcellular Location Cytoplasm.
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium.
Database Links

HGNC: 4684

OMIM: 601244

KEGG: hsa:2977

STRING: 9606.ENSP00000431245

UniGene: Hs.24321

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