Madcam1 Antibody

Code CSB-PA013308ZA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Madcam1 Polyclonal antibody
Uniprot No.
Target Names
Madcam1
Alternative Names
Madcam1Mucosal addressin cell adhesion molecule 1 antibody; MAdCAM-1 antibody; rMAdCAM-1 antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus
Immunogen
Recombinant Rattus norvegicus Madcam1 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.
Gene References into Functions
  1. Immunohistochemical analysis of MAdCAM-1 expression during acute rejection on small bowel grafts in rats PMID: 12034298
  2. Treatment with an antibody to this antigen reduces glomerular and tubulointerstitial scarring in a rat model of crescentic glomerulonephritis PMID: 12368200
  3. Our model of chronic food allergy revealed that lymphocyte migration was increased with MAdCAM-1 upregulation. PMID: 14670821
  4. During small bowel allograft rejection., FTY720 was found to prevent the down-regulation of MAdCAM-1 expression in endothelial venules PMID: 16387148
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Detected in Peyer patches and mesenteric lymph nodes but not in spleen.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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