NAV1 Antibody

Code CSB-PA015478XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NAV1 Polyclonal antibody
Uniprot No.
Target Names
NAV1
Alternative Names
NAV1 antibody; KIAA1151 antibody; KIAA1213 antibody; POMFIL3 antibody; STEERIN1Neuron navigator 1 antibody; Pore membrane and/or filament-interacting-like protein 3 antibody; Steerin-1 antibody; Unc-53 homolog 1 antibody; unc53H1 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) NAV1 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May be involved in neuronal migration.
Gene References into Functions
  1. The +TIP Navigator 1 (NAV1) is important for neurite outgrowth and interacts and colocalizes with TRIO, a Rho guanine nucleotide exchange factor that enables neurite outgrowth by activating the Rho GTPases Rac1 and RhoG. PMID: 25065758
  2. NAV1 forms a complex with the RhoGEF TRIO and the +TIP EB1 on the plus ends of growing microtubules, and regulates TRIO-mediated Rac1 activation and neurite outgrowth. PMID: 25065758
  3. cloning of the gene neuron navigator-1 (NAV1), a human homolog of unc-53, a gene involved in axon guidance in Caenorhabditis elegans PMID: 12079279
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Nav/unc-53 family
Tissue Specificity
Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta.
Database Links

HGNC: 15989

OMIM: 611628

KEGG: hsa:89796

STRING: 9606.ENSP00000356265

UniGene: Hs.585374

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