NAV1

NAV1 refers to the Nav1 family of voltage-gated sodium channels, which are crucial for the generation and conduction of action potentials in neurons. The full name of this protein is "Neuron Navigator 1," and it is commonly known as Nav1. These channels play a pivotal role in the nervous system by regulating the flow of sodium ions across the cell membrane, thereby controlling neuronal excitability. The mechanism of action involves the voltage-dependent activation and inactivation of these channels, which is modulated by various factors including voltage, ligands, and second messengers. NAV1 channels are involved in numerous signaling pathways, including those related to pain, inflammation, and neurological disorders. In terms of diseases, mutations in NAV1 genes can lead to various conditions such as epilepsy, neuropathic pain, and cardiac arrhythmias. Drug development targeting NAV1 channels has been ongoing, with efforts to develop subtype-specific inhibitors for therapeutic applications.