NAV1 Antibody

Code CSB-PA070186
Size US$100
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Product Details

Uniprot No.
Target Names
NAV1
Alternative Names
NAV1 antibody; KIAA1151 antibody; KIAA1213 antibody; POMFIL3 antibody; STEERIN1Neuron navigator 1 antibody; Pore membrane and/or filament-interacting-like protein 3 antibody; Steerin-1 antibody; Unc-53 homolog 1 antibody; unc53H1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human Neuron Navigator 1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in neuronal migration.
Gene References into Functions
  1. The +TIP Navigator 1 (NAV1) is important for neurite outgrowth and interacts and colocalizes with TRIO, a Rho guanine nucleotide exchange factor that enables neurite outgrowth by activating the Rho GTPases Rac1 and RhoG. PMID: 25065758
  2. NAV1 forms a complex with the RhoGEF TRIO and the +TIP EB1 on the plus ends of growing microtubules, and regulates TRIO-mediated Rac1 activation and neurite outgrowth. PMID: 25065758
  3. cloning of the gene neuron navigator-1 (NAV1), a human homolog of unc-53, a gene involved in axon guidance in Caenorhabditis elegans PMID: 12079279
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Nav/unc-53 family
Tissue Specificity
Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta.
Database Links

HGNC: 15989

OMIM: 611628

KEGG: hsa:89796

STRING: 9606.ENSP00000356265

UniGene: Hs.585374

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