Nedd4 Antibody

Datasheet

Code	CSB-PA894280XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Nedd4 Polyclonal antibody

Uniprot No.

Q9VVI3

Target Names

Nedd4

Alternative Names

Nedd4 antibody; CG7555 antibody; E3 ubiquitin-protein ligase Nedd-4 antibody; DNedd4 antibody; EC 2.3.2.26 antibody; HECT-type E3 ubiquitin transferase NEDD4 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Nedd4 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation.

Gene References into Functions

miR-1-mediated regulation of Nedd4/Nedd4L expression may serve to broadly modulate the trafficking or degradation of Nedd4/Nedd4L substrates in the heart PMID: 28246214
Nedd4Lo destabilizes Amph in muscles, leading to impaired T-tubule formation and muscle function. PMID: 26823013
NEDD4 controls the Hippo pathway leading to coordinated cell proliferation and apoptosis PMID: 25692647
data in two evolutionarily distant model organisms strongly suggest that Nedd4 is a modifier of alpha-synuclein pathobiology and thus a potential target for neuroprotective therapies PMID: 24388974
Nedd4, another E3 ubiquitin ligase that may have a role in PD, is functionally related to Sep4 and could be involved in regulating Sep4 subcellular localization/trafficking. PMID: 22562816
splice isoforms of the same dNedd4 gene can lead to opposite effects on neuromuscular synaptogenesis PMID: 22110599
Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation. PMID: 15620649

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Subcellular Location

Cytoplasm.

Tissue Specificity

Ubiquitously expressed.

Database Links

KEGG: dme:Dmel_CG42279

STRING: 7227.FBpp0289746

UniGene: Dm.988

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Email: [email protected]
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Service

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Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

Ubiquitin mediated proteolysis Endocytosis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Nedd4 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background