NEFM Antibody

Code CSB-PA015691ZA01HU
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NEFM Polyclonal antibody
Uniprot No.
Target Names
NEFM
Alternative Names
150kDa medium antibody; 160 kDa neurofilament protein antibody; 2 kDa neurofilament protein antibody; 200 kDa neurofilament protein antibody; 68 kDa neurofilament protein antibody; AI847934 antibody; CMT1F antibody; CMT2CC antibody; CMT2E antibody; FLJ53642 antibody; KIAA0845 antibody; light molecular weight neurofilament protein antibody; Micro glutamic acid-rich protein antibody; mKIAA0845 antibody; Nef3 antibody; NEFH antibody; NEFL antibody; NEFM antibody; Neurofilament 3 antibody; Neurofilament heavy polypeptide 200kDa antibody; Neurofilament heavy polypeptide antibody; Neurofilament light polypeptide 68kDa antibody; Neurofilament light polypeptide antibody; Neurofilament medium polypeptide 150kDa antibody; Neurofilament medium polypeptide antibody; Neurofilament protein heavy polypeptide antibody; Neurofilament protein light chain antibody; Neurofilament protein light polypeptide antibody; Neurofilament protein medium polypeptide antibody; neurofilament subunit NF-L antibody; Neurofilament triplet H protein antibody; Neurofilament triplet L protein antibody; Neurofilament triplet M protein antibody; neurofilament-3 (150 kD medium) antibody; NF-H antibody; NF-L antibody; NF-M antibody; NF160 antibody; NF165 antibody; NF200 antibody; NF68 antibody; NFH antibody; NFL antibody; NFM antibody; NFM_HUMAN antibody; PPP1R110 antibody; protein phosphatase 1, regulatory subunit 110 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens NEFM protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Gene References into Functions
  1. Study determined that spinophilin binding to neurofilament medium required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5. PMID: 28634551
  2. NEFM is a negative regulator of aldosterone production and cell proliferation, in part by facilitating D1R internalization from the plasma membrane in Adosterone-producing Adenomas. PMID: 28584012
  3. There was a strongly elevated reactivity against neurofilament medium in a subset of schizophrenia patients compared to controls. PMID: 24636402
  4. direct evidence that NF-M/H are hyperphosphorylated in Alzheimer disease PMID: 20624930
  5. the importance of alpha-internexin and NF-L in regulating the conformations of NF-M and NF-H PMID: 20213320
  6. This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
  7. To study if the increase of levels of neurofilament (NF)-M and NF-L in brain of Alzheimer's diseases (AD) is caused by increase of NF-M and NF-L. PMID: 12133495
  8. Two polymorphisms of neurofilament M(Ala475Thr and Gly697Arg) occurred at similar frequencies in PD patients and controls. A Pro725Gln substitution and a deletion of valine in position 829 were identified in two PD patients. PMID: 14583397
  9. The G336S variant of hNF-M does not affect the formation of IF networks nor the distribution of the variant hNFM protein. If the G336S variant is involved in the development of PD, it isn't due to defects in the assembly and distribution of NFs. PMID: 15290901
  10. O-glycosylation of NF-M is highly dynamic and closely interwoven with phosphorylation cascades and may have a pathophysiological role. PMID: 16006557
  11. mutations in neurofilaments are possible risk factors that may contribute to pathogenesis in amytrophic lateral sclerosis in conjunction with one or more additional genetic or environmental factors, but are not significant primary causes PMID: 16084104
  12. variation in NEF3 influence rate of response to typical antipsychotic medication PMID: 16734940

Show More

Hide All

Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, axon.
Protein Families
Intermediate filament family
Database Links

HGNC: 7734

OMIM: 162250

KEGG: hsa:4741

STRING: 9606.ENSP00000221166

UniGene: Hs.458657

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X