pha-4 Antibody

1. results suggest that PHA-4 employs feed-forward loops to fine-tune gene expression and instil robustness in the system during energy crisis. PMID: 25504288
2. these results suggest that Pol II recruitment, in addition to chromatin opening, is an important feature of PHA-4 pioneer factor activity. PMID: 26089518
3. PHA-4 binding and activation of pharyngeally expressed promoters was restricted to a subset of pharyngeal cells and excluded from the intestine. PMID: 20714352
4. features of PHA-4 response elements PMID: 20623595
5. Thousands of binding sites for PHA-4 during formation of the embryonic pharynx and a role for this factor during the starvation response, were identified. PMID: 20174564
6. data suggest that PHA-4 and DAF-12 endow the pharynx with transcriptional plasticity to respond to diverse developmental and physiological cues PMID: 15375261
7. The transcription factor PHA-4, functions together with various cis-regulatory elements in target genes to regulate spatial and temporal patterning during development of the pharynx. PMID: 15693952
8. the PHA-4 amino terminus is essential for PHA-4 function in vivo, possibly as a transactivation domain, and can compensate for loss of the carboxyl terminus PMID: 16127716
9. restriction of early blastomeres to the pharyngeal fate depends on both repression of ectodermal genes and activation of pharyngeal genes by PHA-4 PMID: 17250823
10. role of PHA-4 in lifespan determination is specific for dietary restriction, because it is not required for the increased longevity caused by other genetic pathways that regulate ageing PMID: 17476212
11. C. elegans pha-4 encodes a FoxA transcription factor that is required to establish the foregut in embryos and to control growth and longevity after birth. PMID: 18804378

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KEGG: cel:CELE_F38A6.1

STRING: 6239.F38A6.1a

UniGene: Cel.17389