pkd-2 Antibody

Code CSB-PA883324XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans pkd-2 Polyclonal antibody
Uniprot No.
Target Names
pkd-2
Alternative Names
pkd-2; pdk-2; Y73F8A.1; Polycystin-2; CePc2; Polycystic kidney disease 2 protein homolog
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans pkd-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Functions as a calcium permeable cation channel. Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as lov-1 and atp-2 in response behavior.
Gene References into Functions
  1. acts as a major calcium-release channel in the endoplasmic reticulum in cells where rapid calcium signaling is required, and is essential in those excitable cells for rapid responses to stimuli (polycystin-2) PMID: 15862350
  2. Both general and cell-type-specific factors govern TRPP2/PKD-2 subcellular distribution by forming at least two steps involving somatodendritic and ciliary sorting decisions. PMID: 16943275
  3. Results demonstrate that somatodendritic and ciliary targeting of PKD-2 requires the transmembrane region of PKD-2 and that the PKD-2 cytosolic termini regulate subcellular distribution and function. PMID: 18037411
  4. 11 mutants found with defects in the ciliary localization (cil) of C. elegans PKD-2, a transient receptor potential polycystin (TRPP) channel PMID: 18407554
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Cell projection, cilium. Cell projection, axon. Cell projection, dendrite. Perikaryon. Endoplasmic reticulum membrane.
Protein Families
Polycystin family
Tissue Specificity
Exclusively expressed in a subset of 3 categories of adult male sensory neurons: ray neurons, hook neurons and head cephalic (CEM) neurons. Expressed in the male tail.
Database Links

KEGG: cel:CELE_Y73F8A.1

STRING: 6239.Y73F8A.1

UniGene: Cel.12535

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