RETNLB Antibody

Code CSB-PA860653ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RETNLB Polyclonal antibody
Uniprot No.
Target Names
RETNLB
Alternative Names
C/EBP epsilon regulated myeloid specific secreted cysteine rich protein precursor 2 antibody; CCGR antibody; Colon and small intestine specific cysteine rich protein antibody; Colon and small intestine-specific cysteine-rich protein antibody; Colon carcinoma related gene protein antibody; Colon carcinoma-related gene protein antibody; Cysteine rich secreted A12 alpha like protein 1 antibody; Cysteine rich secreted protein A12 alpha like 1 antibody; Cysteine rich secreted protein FIZZ2 antibody; Cysteine-rich secreted protein A12-alpha-like 1 antibody; Cysteine-rich secreted protein FIZZ2 antibody; FIZZ1 antibody; FIZZ2 antibody; Found in inflammatory zone 1 antibody; HXCP2 antibody; RELM beta antibody; RELMb antibody; RELMbeta antibody; Resistin like beta antibody; Resistin like protein beta antibody; Resistin-like beta antibody; RETNB_HUMAN antibody; RETNL2 antibody; Retnlb antibody; XCP2 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens RETNLB protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Probable hormone.
Gene References into Functions
  1. The human mesangial cells with up-regulated and down-regulated expression of RELM-beta increased or decreased significantly at 2-3 days. PMID: 28801998
  2. RELMbeta-overexpression can facilitate invasion and migration of gastric carcinoma cells. PMID: 27001185
  3. RELMbeta levels were increased in Abdominal aortic aneurysm patients in the serum and in the aortic tissue. Increased RELMbeta levels may be involved in the pathogenesis of AAA formation and progress. PMID: 25479529
  4. The data demonstrated that RELM-a is a promising novel biomarker of angiogenesis in patients with gastric cancer. PMID: 25937206
  5. elevated RELM-beta expression in asthmatic airways contributes to airways remodelling at least partly by increasing fibroblast proliferation and differentiation with resulting deposition of extracellular matrix proteins. PMID: 25545115
  6. It is concluded that proper exercise training prevents up-regulation of FIZZ1/RELMalpha induced by cigarette smoking, which may be involved in the mechanism of proper exercise training modulating airway hyperresponsiveness. PMID: 23392702
  7. RELMbeta is abundantly expressed in foam cells within plaques and contributes to atherosclerosis development via lipid accumulation and inflammatory facilitation. PMID: 23702657
  8. Epithelial cell derived Fizz1 transgene is sufficient to increase bone-marrow derived dendritic cells in the lungs. PMID: 22726462
  9. RELM-beta may play an important role not only in animal models of airway remodelling, but also in human airway pathology. PMID: 22758223
  10. RELM-beta has the potential to contribute to airway remodelling in diseases such as asthma by acting on epithelial cells to increase proliferation, mucin and growth factor production, at least partly via ERK/MAPK-PI3K/Akt signalling pathways. PMID: 21828035
  11. Data show that over-expression of RELMbeta abolishes the invasion, metastasis and angiogenesis of gastric cancer cells in vitro. PMID: 22371635
  12. High RELMbeta is associated with colorectal cancer. PMID: 21094111
  13. FIZZ2 is highly induced in lungs of human patients with idiopathic pulmonary fibrosis. PMID: 21602491
  14. Gastric cncer patients showing positive RELMbeta expression had a significantly longer overall survival than those with negative expression (P = 0.001). PMID: 19967544
  15. High levels of RELMbeta can be detected in the stool of mice and humans, where it exists as a homodimer under nonreducing conditions. PMID: 14598255
  16. Of the 80 colon cancer patients studied, 65 (81.25%) tested positive for RELM beta, mainly in the cytoplasm of colon mucosa. PMID: 18594973
  17. Results suggest that RELM-beta may be involved in the development of scleroderma-associated pulmonary hypertension. PMID: 19251945
  18. Supernatant from COS cells transfected with the CCRG (RETNLB) expression vector stimulated proliferation of colon cancer cells, which supports the growth factor nature of the RETNLB gene. PMID: 12224133

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Subcellular Location
Secreted.
Protein Families
Resistin/FIZZ family
Tissue Specificity
Expressed only in the gastrointestinal tract, particularly the colon.
Database Links

HGNC: 20388

OMIM: 605645

KEGG: hsa:84666

STRING: 9606.ENSP00000295755

UniGene: Hs.307047

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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