rnb Antibody

Datasheet

Code	CSB-PA007787XA01ENV
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Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) rnb Polyclonal antibody

Uniprot No.

P30850

Target Names

rnb

Alternative Names

rnb antibody; b1286 antibody; JW1279 antibody; Exoribonuclease 2 antibody; EC 3.1.13.1 antibody; Exoribonuclease II antibody; RNase II antibody; Ribonuclease II antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) rnb protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. RNases 2 and R (rnr) contribute to rRNA degradation during starvation, while RNase R and PNPase (pnp) are the major contributors to quality control of rRNA during steady state growth. This RNase is required to decrease expression of RNase PH (rnp) at 42 degrees Celsius during starvation, which in turn represses rRNA degradation.

Gene References into Functions

Reversible acetylation on Lys501 regulates the activity of RNase II. PMID: 26847092
We determined that the deletion of RNase II significantly affected 187 transcripts, while deletion of RNase R affects 202 transcripts and deletion of PNPase affected 226 transcripts PMID: 25757888
Data show that RNase II is associated with all of the known degradosome proteins. PMID: 25299745
Data indicate that membrane association and self-interactions are both required for the RNase II cellular organization. PMID: 23344958
A functionl characterization of three different domains assigned to the Escherichia coli RNase II - two RNA-binding domains at each end of the protein (CSD and S1), and a central RNB catalytic domain - was performed PMID: 16806266
The crystal structure of E. coli RNase II reveals an architecture reminiscent of the RNA exosome. PMID: 16996291
The authors propose that RNase II degrades mRNA to the downstream border of paused ribosomes, facilitating cleavage of the A-site codon by an unknown RNase. PMID: 19627501

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Subcellular Location

Cytoplasm.

Protein Families

RNR ribonuclease family, RNase II subfamily

Database Links

KEGG: ecj:JW1279

STRING: 316385.ECDH10B_1403

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Service

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Antibody Service

Protein Service

Gene Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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rnb Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background