Tead4 Antibody

1. TEAD4 mediated the interaction between YAP1 and c-JUN. YAP1 and the YAP1-TEADs complex have roles in regulating osteoclastogenesis and related gene expression. PMID: 29432919
2. Based on the similarity to a related family member, and in vitro transcription/translation product(s), the authors propose that translation initiates from a non-AUG (AUA or AUU) start codon. PMID: 8920920
3. AP-1- and TEAD4-associated cis-regulatory elements form hubs for multiple signalling-responsive transcription factors and define the cistrome that regulates vascular and hematopoietic development by extrinsic signals. PMID: 27802171
4. Dual-luciferase reporter gene analysis showed that RTEF-1 is a direct target of mir-125a-5p, which regulates angiogenesis by repressing RTEF-1 expression and modulating eNOS and VEGF expression. PMID: 25059272
5. TEAD4 establishes the energy homeostasis essential for blastocoel formation. PMID: 23903192
6. These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels. PMID: 22843786
7. Vgll1 interacts with TEAD4 in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1 has the potential to promote cancer progression. PMID: 22632831
8. endothelial-specific RTEF-1 overexpressing mice had enhanced angiogenic sprouting and vascular structure remodeling, resulting in the formation of a denser and more highly interconnected superficial capillary plexus PMID: 22652601
9. Data suggest that altered subcellular localization of TEAD4 in blastomeres dictates first mammalian cell fate specification. PMID: 22529382
10. TEAD factors directly induce Myogenin, CDKN1A and Caveolin 3 expression to promote myoblast differentiation. PMID: 21701496
11. Gata3 and Cdx2 can act in parallel pathways downstream of Tead4 to induce the expression of common and independent targets in the trophoblast lineage, whereas Oct4 is required for continued repression of trophoblast fate in the embryonic lineage PMID: 20081188
12. Novel RTEF-1 transcripts are present within human ocular vascular endothelial cells and mouse neural retina during normal and retinopathy of prematurity development, and alternatively spliced products are produced under hyperoxic and hypoxic conditions PMID: 17652751
13. RTEF-1 regulated smooth muscle alpha-actin transcription in myofibroblasts, but not in differentiated smooth muscle PMID: 17823374
14. Tead4 is the earliest gene shown to be uniquely required for specification of the trophectoderm lineage PMID: 17913785
15. Tead4 has a distinct role from Tead1 and Tead2 in trophectoderm specification of pre-implantation embryos; it is an early transcription factor required for specification and development of the trophectoderm lineage, which includes expression of Cdx2. PMID: 18083014

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KEGG: mmu:21679

STRING: 10090.ENSMUSP00000006311

UniGene: Mm.14774