Trex1 Antibody

1. Trex1 is an upstream regulator of radiation-driven anti-tumor immunity. Trex1 induction may guide the selection of radiation dose and fractionation in patients treated with immunotherapy. PMID: 28598415
2. the cell-cycle-dependent post-translation modification of TREX1 regulates its interaction with OST. PMID: 28297665
3. The effect of topical TREX1 knockdown and local interferon production on HIV transmission in human cervicovaginal explants and humanized mice, is reported. PMID: 27184854
4. data do not support the concept of retroelement-derived cDNA as key triggers of systemic autoimmunity in Trex1-deficient humans and mice PMID: 28835460
5. Trex1 expression in dendritic cells is essential to prevent breakdown of self-tolerance ensuing from aberrant detection of endogenous DNA. PMID: 27511730
6. Data show that oligosaccharyltransferase (OST) activity is dysregulated in three prime exonuclease 1 knockout (Trex1-/-) cells. PMID: 26320659
7. Data show that cyclic GMP-AMP synthase (cGAS) is essential for all aspects of the autoimmune disease in 3' repair exonuclease Trex1 knockout mice. PMID: 26223655
8. Dysfunctional dsDNA degradation by TREX1 D18N induces disease in mice that recapitulates many characteristics of human lupus. PMID: 25848017
9. knocking out the DNA sensor cyclic GMP-AMP synthase completely abrogates spontaneous induction of IFN-stimulated genes in TREX1-deficient cells. PMID: 24813208
10. Spontaneous type I INF dependent cutaneous pathology in TREX1 deficiency illustrates common pathogenetic pathway in chilblain lupus. PMID: 24270665
11. Upon proinflammatory stimulation, Trex1(-/-) macrophages increase CD86, TNF-alpha & IFN-alpha production, & Ag presentation to CD4(+) T cells, but decrease apoptotic T cell clearance. Trex1 is a negative regulator of macrophage inflammatory activation. PMID: 24218451
12. Oxidized DNA Is less susceptible to TREX1 degradation; the oxidized base 8-hydroxyguanosine, a marker of oxidative damage in DNA, potentiated cytosolic immune recognition by decreasing its susceptibility to 3' repair exonuclease 1 -mediated degradation PMID: 23993650
13. regulates lysosomal biogenesis and interferon-independent activation of antiviral genes PMID: 23160154
14. The structures of the mutant TREX1 proteins provide insight into the dysfunction relating to human disease. PMID: 22071149
15. TREX1 bound to cytosolic HIV DNA and digested excess HIV DNA that would otherwise activate interferon expression via a pathway dependent on the kinase TBK1, the adaptor STING and the transcription factor IRF3 PMID: 20871604
16. Trex1(-/-) mice exhibit a dramatically reduced survival and develop inflammatory myocarditis leading to progressive, often dilated, cardiomyopathy and circulatory failure PMID: 15254239
17. Study defines Trex1 as an essential negative regulator of the IFN-stimulatory DNA response and delineate the genetic pathway linking Trex1 deficiency to lethal autoimmunity. PMID: 18724932
18. Study showed that GFP-TREX1-(1-307) lacking the C-terminal seven amino acids localizes in a perinuclear pattern. PMID: 19442247

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KEGG: mmu:22040

STRING: 10090.ENSMUSP00000050971

UniGene: Mm.439964