TREX1

TREX1, also known as three - prime repair exonuclease 1, is an important protein. Commonly, it's also referred to as DNase III. This protein acts as a 3' to 5' exonuclease, degrading single - stranded DNA. It is involved in DNA repair and maintaining genomic stability. The cGAS - STING pathway is associated with TREX1, where TREX1 prevents excessive activation of this pathway by degrading DNA.
Mutations in TREX1 are linked to several diseases, such as Aicardi - Goutieres syndrome, chilblain lupus, and systemic lupus erythematosus. In drug development, researchers are exploring inhibitors or activators to regulate TREX1 activity, aiming to treat these related diseases and improve patients' conditions.