Wnt4 Antibody

1. At different points of development, dWnt4 switches from using the non-canonical pathway components to using a beta-catenin-dependent canonical pathway in the escort cells to facilitate the proper differentiation of Germline stem cells. PMID: 29370168
2. disruption of Wnt4 and components of the canonical Wnt pathway results in a complex germ cell phenotype marked by an expansion of germline stem cell-like cells, pre-cystoblasts and cystoblasts in young females. PMID: 27364467
3. Wnt4 and the canonical Wnt signaling pathway are essential for ostia formation in Drosophila PMID: 26994311
4. dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche. PMID: 27019121
5. this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression. PMID: 24436419
6. Wg and Wnt4 act redundantly in planar cell polarity determination in Drosophila. PMID: 23912125
7. We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm. PMID: 22371299
8. In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning. PMID: 21772251
9. It works as a negative signal in neural connectivity. (review) PMID: 21089332
10. DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. PMID: 11970894
11. DWnt4 antagonizes the polarizing effect of four-jointed PMID: 15986451
12. in DWnt4 mutants, ventral retinal axons misprojected to the dorsal lamina PMID: 16369482

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KEGG: dme:Dmel_CG4698

STRING: 7227.FBpp0088345

UniGene: Dm.341